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The NLRP3 Inflammasome: An Attentive Arbiter of Inflammatory Response
Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer's disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mech...
Frontiers in Clinical Drug Research: Diabetes and Obesity
Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and ...
Pain: Causes, Concerns and Consequences
Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized me...
Depression: A Silent Culprit in Health and Disease
Depression is considered as a complex problem with potentially serious economic consequences for affected individuals as well as public healthcare systems. There is much debate among laypersons, patients, academics and clinicians about the causes of depression, its clinical significance and the effect of conventional medical interventions such as antidepressants. This monograph showcases some aspects of depression through specific reviews on some of the intricacies behind its mechanism. The book includes five reviews on the subject, covering the significance of depression in patient well-being, an update on P300 wave findings and the link with clinical depression, the genomics behind depression, the effects of ageing on the onset of depression in stroke patients, and tensor imaging techniques used in studies on patients exhibiting suicidal behaviors as a result of major depressive disorder. This reference provides useful updates for healthcare workers, neuroscientists and behavioral scientists interested in basic research on depression and in planning to develop methods to study depression in either a clinical or laboratory setting
Sustainable Development Through Engineering Innovations
This book comprises select peer-reviewed papers presented at the International Conference on Sustainable Development through Engineering Innovations (SDEI) 2020. It presents recent advances, new directions, and opportunities for sustainable and resilient approaches to design and protect the built-environment through engineering innovations & interventions. The topics covered are highly diverse and include all civil engineering and construction-related aspects such as construction and environmental Issues, durability and survivability under extreme conditions, design of new materials for sustainability, eco-efficient and ultra-high performance cementitious materials, embedded structural and foundation systems and environmental geomechanics. The book will be of potential interest to the researchers and students in the fields of civil engineering, architecture and sustainable development.
Proceedings of the 1st International Conference on Sustainable Waste Management through Design
This book describes the latest advances, innovations and applications in the field of waste management and environmental geomechanics as presented by leading researchers, engineers and practitioners at the International Conference on Sustainable Waste Management through Design (IC_SWMD), held in Ludhiana (Punjab), India on November 2-3, 2018. Providing a unique overview of new directions, and opportunities for sustainable and resilient design approaches to protect infrastructure and the environment, it discusses diverse topics related to civil engineering and construction aspects of the resource management cycle, from the minimization of waste, through the eco-friendly re-use and processing ...
Osteoporosis, Osteoarthritis and Rheumatoid Arthritis: An Agonizing Skeletal Triad
This comprehensive compendium unravels the intricacies of three common and daunting skeletal disorders: osteoporosis, osteoarthritis, and rheumatoid arthritis. These ailments afflict people across all age groups, demanding a deeper understanding of their diagnostic, prognostic, preventive, and therapeutic dimensions. It presents seven key topics written by medical experts that explore research on these diseases: Chronic Lung Disease and Osteoporosis An exploration of the intricate link between chronic lung ailments and osteoporosis. AI Detection of Knee Osteoarthritis Recent use of artificial intelligence aiding knee osteoarthritis identification. Inflammatory Signalling in Rheumatoid Arthri...
