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Chemoinformatics Approaches to Structure- and Ligand-Based Drug Design
Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.
Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease
The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two level...
Circulation
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Hungarian Borderlands
An in-depth examination of border decomposition, re-creation and destruction in 20th-century Hungary.
Debordering and Rebordering
This book addresses practices of bordering, debordering and rebordering on the territory of the former Austro-Hungarian Monarchy after state borders had been remapped on the negotiation tables of the Paris Peace Treaties following the First World War. As life in borderlands did not correspond to the peaceful Europe articulated in the Paris Treaties, a multitude of (un)foreseen complications followed the drawing of borders and states. The chapters in this book include new case studies on the creation, centralization or peripheralization of border regions, such as Subcarpathian Rus, Vojvodina, Banat and the Carpathian Mountains; on border zones such as the Czechoslovakian harbour in Germany; a...
The Disputed Austro-Hungarian Border
The collapse of the Habsburg monarchy in the aftermath of World War I marked a foundational shift in the histories of Austria and Hungary. Previously part of the Habsburg’s Austro-Hungarian Empire, this event stripped the two new states of a long-established territorial order, triggering a controversial redrawing of their borders. Whilst scholarship often focuses on the role played by state actors in Vienna and Budapest, The Disputed Austro-Hungarian Border refreshingly re-examines this event through investigating how processes of state and nation-building manifested within the contested region of Western Hungary and Burgenland. In doing so, this book innovatively resituates this border region within the larger context of post-Habsburg historical development taking place across Central Europe.
Traitors, Collaborators and Deserters in Contemporary European Politics of Memory
This volume offers a multidisciplinary approach to shaping and imposition of “formulas for betrayal” as a result of changing memory politics in post-war Europe. The contributors, who specialize in history, sociology, anthropology, memory studies, media studies and cultural studies, discuss the exertion of political control over memory (including the selection, imposition, silencing or ideological “twisting” of facts), the usage of “formulas for betrayal” in various cultural-political contexts, and the discursive framing of the betraying subject for the purpose of legitimizing various memory regimes and ideologies.
