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Metalloproteins
Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role
The Positive Deviant
An economy low in carbon and high in life satisfaction will require thousands, if not millions of exceptional leaders. This book is the first to bring together sustainability knowledge with the leadership skills and tools to help you become one of those leaders. In it you will find everything you need to get started straight away, and to grow your effectiveness, even in a world that remains perversely intent on the opposite. Whether you are new to the whole idea of sustainability, or reasonably well informed but not entirely confident about what to do for the best, this guide will help you 'do' sustainability. Free of checklists and policy recommendations, the focus is on you, and on developing your capacity to identify the right thing to do wherever you are and whatever your circumstances. This is essential reading for those in or aspiring to sustainability-literate leadership, and a must for all those teaching leadership and management.
Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing
The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.
Mucosal Immunology
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix
Self-Assembly of Nanostructures and Patchy Nanoparticles
Top-down approaches are currently the main contributor of fabricating microelectronic devices. However, the prohibitive cost of numerous technological steps in these approaches is the main obstacle to further progress. Furthermore, a large number of applications necessitate fabrication of complex and ultra-small devices that cannot be made using these approaches. New approaches based on natural self-assembly of matter need to be developed to allow for fabrication of micro and nanoelectronic devices. Self-assembly of nanostructures is a dynamic field, which explores physics of these structures and new ways to fabricate them. However, the major problem is how to control the properties of the nanostructures resulting from low dimensionality. This book presents recent advances made to address this problem, and fabricate nanostructures using self-assembly.
Amino Acids and Their Derivatives in Higher Plants
For 150 years scientists at the Rothamsted Experimental Station have studied aspects of plant nitrogen nutrition and amino acid biosynthesis. This book is the result of a meeting held to mark this century and a half of work there. The papers look at the significant progress in understanding the biochemistry of amino acids recently achieved, in the light of this history of research. Leading researchers from around the world have contributed authoritative chapters on protein amino acids, non-protein amino acids, betaines, glutathione, polyamines and other secondary metabolites derived from amino acids. As well as being essential in some animals' nutrition, these compounds can have important roles in defending against herbivores, insects and disease. An understanding of these compounds can help in devising better crop protection and production methods.
Redesigning the Clinical Effectiveness Research Paradigm
Recent scientific and technological advances have accelerated our understanding of the causes of disease development and progression, and resulted in innovative treatments and therapies. Ongoing work to elucidate the effects of individual genetic variation on patient outcomes suggests the rapid pace of discovery in the biomedical sciences will only accelerate. However, these advances belie an important and increasing shortfall between the expansion in therapy and treatment options and knowledge about how these interventions might be applied appropriately to individual patients. The impressive gains made in Americans' health over the past decades provide only a preview of what might be possib...
