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Neuronal Self-Defense: Compensatory Mechanisms in Neurodegenerative Disorders
Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain's function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mech...
Reading the Reverse Fa?e of Reims Cathedral
Though long recognized as one of the most beautiful works from the second half of the thirteenth century, the magnificent sculptural program of the reverse fa?e at Reims Cathedral has received little in the way of scholarly attention. Interpreting the iconography in the light of Latin texts associated with the building, its history and its ceremonial use, Donna Sadler assesses the significance of the reverse fa?e in light of other thirteenth-century visual programs associated with the court of Louis IX. The book's chapters deal with the history of the cathedral and its architectural antecedents; the iconographic message of the visual program, the meaning of the reverse fa?e and how it inters...
Surfing the Edge of Chaos
Every few years a book changes the way people think about a field. In psychology there is Daniel Goleman's Emotional Intelligence. In science, James Gleick's Chaos. In economics and finance, Burton Malkiel's A Random Walk Down Wall Street. And in business there is now Surfing the Edge of Chaos by Richard T. Pascale, Mark Millemann, and Linda Gioja. Surfing the Edge of Chaos is a brilliant, powerful, and practical book about the parallels between business and nature -- two fields that feature nonstop battles between the forces of tradition and the forces of transformation. It offers a bold new way of thinking about and responding to the personal and strategic challenges everyone in business f...
Complexity and Organization
In the past decade, complexity-based thinking has exerted an increasing, yet somewhat controversial authority over management theory and practice. This has in some part been due to the influence of a number of high-profile articles and the not inconsiderable hype which has accompanied them. Another feature of the subject’s development has been the diversity of the origins of the thinking and the claims which have been made for it in terms of managerial and organizational implications. Complexity and Organization is the first text to bring this thinking together, presenting some of the most influential writing in the field, showing how the subject has developed and how it continues to influ...
R. Edward Freeman’s Selected Works on Stakeholder Theory and Business Ethics
Ed Freeman’s influential ideas on stakeholder theory, business ethics, humanities, and capitalism became foundational in the management field and turned around the mainstream thinking about business. Stakeholder theory developed by Freeman and others posits that business is not as much about profits, but rather about creating value for its stakeholders, including employees, customers, communities, financiers, and suppliers. The relationship between a company and its stakeholders is the essence of business and should be of utmost attention to its managers. Managers should avoid resorting to trade-offs by prioritizing one stakeholder group (e.g., shareholders) over the others and strive to run their companies in the interests of all stakeholders. The idea of pursuing the interests of all stakeholders became revolutionary in management and went far beyond the management field, expanding to Law, Health Care, Education, Public Policy and Administration, and Environmental Policy. This book is a collection of Ed Freeman’s most influential and important works on stakeholder theory as well as business ethics, humanities, and capitalism.
Cancer Research
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