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Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins
TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifier...
Migration between Africa and Europe
This volume examines migration between Africa and Europe, rather than just from Africa to Europe. Based on a unique socio-demographic survey carried out both in origin and destination countries (MAFE survey), it argues that return migration, circulation, and transnational practices are significant. Policy design must also take these factors into account. Comparing in a systematic way three flows of African migrants (from Democratic Republic of Congo, Ghana and Senegal), this study offers a new view on the patterns, determinants, and family and economic effects of migration. By comparing six European countries (Belgium, France, Italy, the Netherlands, Spain and the UK), it shows that the dynamics of migration differ greatly in new vs. old destination countries. Based on a statistical analysis of life histories, this study provides a dynamic view of migration that will help readers better understand current trends as well as future trajectories. It will appeal to researchers, academics, practitioners, and others interested in taking a deeper look in (im)migration issues.
Handbook of Research on Didactic Strategies and Technologies for Education: Incorporating Advancements
"This book is designed to be a platform for the most significant educational achievements by teachers, school administrators, and local associations that have worked together in public institutions that range from primary school to the university level"--Provided by publisher.
Fundamental Approaches to Software Engineering
ETAPS 2002 was the ?fth instance of the European Joint Conferences on Theory and Practice of Software. ETAPS is an annual federated conference that was established in 1998by combining a number of existing and new conferences. This year it comprised 5 conferences (FOSSACS, FASE, ESOP, CC, TACAS), 13 satellite workshops (ACL2, AGT, CMCS, COCV, DCC, INT, LDTA, SC, SFEDL, SLAP, SPIN, TPTS, and VISS), 8invited lectures (not including those speci?c to the satellite events), and several tutorials. The events that comprise ETAPS address various aspects of the system - velopment process, including speci?cation, design, implementation, analysis, and improvement. The languages, methodologies, and tools which support these - tivities are all well within its scope. Di?erent blends of theory and practice are represented, with an inclination towards theory with a practical motivation on one hand and soundly-based practice on the other. Many of the issues involved in software design apply to systems in general, including hardware systems, and the emphasis on software is not intended to be exclusive.
The Essentials of Contract Negotiation
This book focuses on the tactics and strategies used in business-to-business contract negotiations. In addition to outlining general negotiation concepts, techniques and tools, it provides insight into relevant framework conditions, underlying mechanisms and also presents generally occurring terms and problems. Moreover, different negotiating styles are illustrated using an exemplary presentation of negotiation peculiarities in China, the USA and Germany. The presented tactics and strategies combine interdisciplinary psychological and economic knowledge as well as findings from the field of communication science. The application scope of these tactics and strategies covers business-to-busine...
Kompetencje Unii Europejskiej a działania ustawodawcze w sferze ustalania wynagrodzenia za pracę
W książce omówiono kompetencje Unii Europejskiej w dziedzinie polityki społecznej, a w szczególności dotyczące wynagrodzenia za pracę. Autorka zwraca uwagę, że państwa członkowskie coraz częściej podnoszą argument dotyczący braku kompetencji Unii Europejskiej do podejmowania działań prawodawczych w przedmiocie wynagrodzenia za pracę. W związku z tym kompleksowo przedstawia zakres wyłączenia zagadnienia wynagrodzenia za pracę z uprawnień Unii, odwołując się do orzecznictwa TSUE oraz przepisów TUE i TFUE. Dokonuje w tym kontekście analizy przyjętych w ostatnim czasie aktów prawnych Unii Europejskiej dotyczących wynagrodzenia za pracę, tj. dyrektywy w sprawie ad...
Oncology Research
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Jak zvládnout 77 obtížných situací při prezentacích a přednáškách
Jak posluchače zaujmout a udržet jejich pozornost? Jak zvládnout trému a pracovat s řečí těla? Jak skloubit obsah a formu vystoupení? Jak prezentovat a přednášet srozumitelně a účinně? Jak zaplnit prázdná místa v prvních řadách? Jak se připravit na různé skupiny posluchačů? Jak se vyvarovat nezájmu a rozladěnosti publika? Jak ideálně připravit prostor? Jak se správně obléci? Jak zvládnout konfliktní posluchače? Jak reagovat na dotazy a námitky? Jak se vyvarovat nejčastějších chyb vystupujících? Jak přistupovat k neformálním aktivitám spojeným s vystoupením? Jak svou řeč elegantně ukončit? To vše a mnohem více se dozvíte ve čtivé knížce plné osvědčených rad a příkladů z praxe. Je určena všem manažerům, obchodníkům, lektorům a všem, kteří pravidelně nebo příležitostně hovoří před publikem, něco prezentují či přednášejí.
EU Equality Law
The European Union is a supranational organisation with a set of circumscribed powers. Although these powers do not include an all-encompassing fundamental rights' mandate, today's existential challenges - from economic to refugee crisis, via concerns for compliance with the rule of law in some of its Member States - increase the pressure on the EU to develop tools for protection and promotion of such rights. One way of addressing the tension between the lack of a general mandate and vivid calls for protection is for the EU to focus on selected fundamental rights which it has competence to regulate. One such example is EU law on the fundamental right to equal treatment that has blossomed since the late 1990s. In developing selected fundamental right policies that can be imposed on domestic actors, as EU law does, supranational intervention needs to be carefully tailored to the plural landscape where they are intended to flourish. This monograph calls for a nuanced use of the infrastructure of EU law to convey shared values at domestic level across Europe.
