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International Review of Cytology
International Review of Cytology
Transgenic Models of Human Viral and Immunological Disease
Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.
Arctic Triumph
This book approaches the challenges the Arctic has faced and is facing through a lens of opportunity. Through pinpointed examples from and dealing with the Circumpolar North, the Arctic is depicted as a region where people and peoples have managed to endure despite significant challenges at hand. This book treats the ‘Arctic of disasters’ as an innovated narrative and asks how the ‘disaster pieces’ of Arctic discourse interact with the ability of Arctic peoples, communities and regions to counter disaster, adversity, and doom. While not neglecting the scientifically established challenges associated with climate change and other (potentially) disastrous processes in the north, this book calls for a paradigm shift from perceiving the ‘Arctic of disasters’ to an ‘Arctic of triumph’. Particular attention is therefore given to selected Arctic achievements that underline ‘triumphant’ developments in the north, even when Arctic triumph and disaster intersect.
Critical Studies of the Arctic
This book is a pioneering effort in critical Arctic studies. The contributions identify and investigate some of the blind spots in human development in the Arctic that research in the social sciences had yet to broach. To this end, the authors tap a variety of critical approaches in fields spanning aesthetics, affect theory, biopolitics, critical geopolitics, Indigenous archaeology, intersectionality, legal anthropology, moral economy, narrative studies, neoliberal governmentality, queer studies and socio-legal studies. The chapters probe topics such as representations of the Arctic in contemporary art, the role of affects in postcolonial Greenland, Canada’s Arctic policies and China’s engagement with the Arctic. The book provides a rich knowledge base for researchers in Arctic social sciences and offers an absorbing textbook for students interested in Arctic issues.
Advances in Mucosal Immunology
The immunology of mucosal surfaces is one of the most exciting and relevant areas of medical veterinary and dental research since it applies basic research to tissues in volved in everyday defence against microbes and against environmental and food antigens. This book is based on the contributions presented at the International Con gress of Mucosal Immunology, held in London in July 1989 and organised by the Mu cosal Immunology Affinity Group of the British Society for Immunology. The meet ing was attended by over 500 delegates from 27 countries, including virtually all of the leading investigators in the field. The contents give comprehensive and up-to date information on such topics as ant...
Turek’s Orthopaedics Principles and Their Applications
Now in its revised, updated Seventh edition, this text provides residents and medical students with a broad overview of adult and pediatric orthopaedics. Major sections focus on general and regional disorders of the musculoskeletal system.
The Genus Yersinia:
The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA, in October 2006. Hundreds of Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas that include genomics and pathogenesis.
Ankylosing spondylitis and Klebsiella
Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria. When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts. This is...
Immunotoxicology and Risk Assessment
This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment by mathematical models and safety factors. It will be a useful reference to toxicologists because it will incorporate new guidelines that the EPA is bringing out later this year for all chemicals regulated under the Federal Insecticide, Fungicide, and Rodenticide Act and the Toxic Substances Control Act. Regulatory sections in each chapter focus on data from both the US Food and Drug Administration, as well as data applicable to western European Nations.
Fibrinolytics and Antifibrinolytics
Disturbances of haemostasis and thromboembolic disorders still constitute a great problem in clinical practice. Increasing insight into the mechanism of blood coagula tion has led to more effective therapy and prophylaxis. Particularly, the understand ing of the biochemistry of fibrinolysis has provided possibilities for the pharma cological interference of these processes, which has resulted in effective haemostatic agents and useful antithrombotic ones. The development of antifibrinolytics for interfering with pathological fibrinolytic processes is nearly complete and has led to the development of drugs essential to the therapy of hyperfibrinolytic bleeding. The search for fibrinolytics fo...
