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Perioperative Fluid Management
This book presents the most recent evidence-based facts on perioperative fluid management and discusses fluid management from basic sciences to clinical applications and the patients’ outcomes. Recent advances in understanding the Revised Starling principle with new concepts in tissue perfusion and the most recent techniques of perioperative goal directed fluid management are described. The endothelial glycocalyx functions and the influence of fluid management on its integrity are covered in detail; moreover, the techniques for its protection are also discussed. The dilemma of perioperative use of hydroxyethyl starch solutions and the resurgence of interest in using human albumin as an alternative colloid is explored. The problems of using unbuffered solutions during the perioperative period and comparison between restrictive versus liberal fluid management are discussed in full. Perioperative Fluid Management will be of interest to anesthesiologists and also intensivists.
Minimally Invasive Surgery of the Foot and Ankle
Minimally Invasive Surgery of the Foot and Ankle represents a novel approach to treatment of orthopedic problems in the foot and ankle. The gradual change of philosophy in the management of foot and ankle surgery means that patients require a less invasive approach to surgery and a consequent improvement in recovery time. Describing the techniques and, importantly, the indications for minimally invasive procedures for the management of foot and ankle ailments, this book will explain the management of various conditions and how they can be approached using minimally invasive techniques. However, rather than only concentrating on minimally invasive surgery of the foot and ankle, the authors will be examining the options open to surgeons operating in this area – both open surgical and arthroscopic – and explaining the benefits of each. Extensive radiographs, diagrams, and intra-operative pictures will illustrate the procedures described.
Operative Techniques in Orthopaedic Surgery
Lavishly illustrated, comprehensive in scope, and easy to use, the second edition of Operative Techniques in Orthopaedic Surgery guides you to mastery of every surgical procedure you’re likely to perform – while also providing a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect. More than 800 global experts take you step by step through each procedure, and 13,000 full-color intraoperative photographs and drawings clearly demonstrate how to perform the techniques. Extensive use of bulleted points and a highly templated format allow for quick and easy reference across each of the four volumes.
Integrative Cardiology
Integrative Cardiology is an exploration of a new and much-needed perspective in cardiac care: the intelligent synthesis of conventional medicine with alternative approaches not typically part of Western medical curriculum. More than a blending of two approaches, this new perspective in cardiology highlights specific gaps in conventional heart care, and examines how alternative approaches may be ideally suited to address these missed opportunities.Cardiology is an ideal specialty for an integrative approach. Heart disease is largely preventable. The influence of nutrition, physical activity, metabolic factors, and emotional state on heart health is unmistakable, and the wide-angle lens of in...
Enabling Precision Medicine
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.
Artery Bypass
The latest diagnostic and therapeutic modalities in the management of coronary artery disease by coronary artery bypass graft surgery and by percutaneous coronary intervention with stenting and in the interventional management of other atherosclerotic vascular disease have led to a reduction in cardiovascular mortality and morbidity. This book entitled Artery Bypass provides an excellent update on these advances which every physician seeing patients with atherosclerotic vascular disease should be familiar with. This book includes 27 chapters written by experts in their topics.
Myocardial Ischemia
Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid expo nential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcrip tional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ische...
Knowing What Works in Health Care
There is currently heightened interest in optimizing health care through the generation of new knowledge on the effectiveness of health care services. The United States must substantially strengthen its capacity for assessing evidence on what is known and not known about "what works" in health care. Even the most sophisticated clinicians and consumers struggle to learn which care is appropriate and under what circumstances. Knowing What Works in Health Care looks at the three fundamental health care issues in the United States-setting priorities for evidence assessment, assessing evidence (systematic review), and developing evidence-based clinical practice guidelines-and how each of these contributes to the end goal of effective, practical health care systems. This book provides an overall vision and roadmap for improving how the nation uses scientific evidence to identify the most effective clinical services. Knowing What Works in Health Care gives private and public sector firms, consumers, health care professionals, benefit administrators, and others the authoritative, independent information required for making essential informed health care decisions.
Oxygen Transport to Tissue XXV
The 30th scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) was held at the Western Conference Centre, UMIST, Manchester, in August 2002. It was attended by some 96 delegates and accompanying persons and there were 128 presentations.
