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We normally think of viruses in terms of the devastating diseases they cause, from smallpox to AIDS. But in The Life of a Virus, Angela N. H. Creager introduces us to a plant virus that has taught us much of what we know about all viruses, including the lethal ones, and that also played a crucial role in the development of molecular biology. Focusing on the tobacco mosaic virus (TMV) research conducted in Nobel laureate Wendell Stanley's lab, Creager argues that TMV served as a model system for virology and molecular biology, much as the fruit fly and laboratory mouse have for genetics and cancer research. She examines how the experimental techniques and instruments Stanley and his colleagues developed for studying TMV were generalized not just to other labs working on TMV, but also to research on other diseases such as poliomyelitis and influenza and to studies of genes and cell organelles. The great success of research on TMV also helped justify increased spending on biomedical research in the postwar years (partly through the National Foundation for Infantile Paralysis's March of Dimes)—a funding priority that has continued to this day.
Bodies and body parts of the dead have long been considered valuable material for use in medical science. Over time and in different places, they have been dissected, autopsied, investigated, harvested for research and therapeutic purposes, collected to turn into museum and other specimens, and then displayed, disposed of, and exchanged. This book examines the history of such activities, from the early nineteenth century through to the present, as they took place in hospitals, universities, workhouses, asylums and museums in England, Australia and elsewhere. Through a series of case studies, the volume reveals the changing scientific, economic and emotional value of corpses and their contested place in medical science.
This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding. We contend that model organisms are key components of a distinctive way of doing research. We focus on what makes model organisms an important type of model, and how the use of these models has shaped biological knowledge, including how model organisms represent, how they are used as tools for intervention, and how the representational commitments linked to their use as models affect the research practices associated with them. This title is available as Open Access on Cambridge Core.
The Man Who Crucified Himself is the history of a sensational nineteenth-century medical case. In 1805 a shoemaker called Mattio Lovat attempted to crucify himself in Venice. His act raised a furore, and the story spread across Europe. For the rest of the century Lovat’s case fuelled scientific and popular debates on medicine, madness, suicide and religion. Drawing on Italian, German, English and French sources, Maria Böhmer traces the multiple readings of the case and identifies various 'interpretive communities'. Her meticulously researched study sheds new light on Lovat’s case and offers fresh insights on the case narrative as a genre - both epistemic and literary.
"What the editors have managed to accomplish with Fundamentals of the Stem Cell Debate is very significant. The book is well-informed, sophisticated, and attends to the moral and scientific complexities of stem cell research, rather than sweeping them under the rug. This book encompasses the complexities without sacrificing the other main virtue of the collection: to definitively illuminate the debate for all."—Jason Scott Robert, author of Embryology, Epigenesis, & Evolution: Taking Development Seriously
A welcome dive into the world of aquarium craft that offers much-needed knowledge about undersea environments. Atlantic coral is rapidly disappearing in the wild. To save the species, they will have to be reproduced quickly in captivity, and so for the last decade conservationists have been at work trying to preserve their lingering numbers and figure out how to rebuild once-thriving coral reefs from a few survivors. Captive environments, built in dedicated aquariums, offer some hope for these corals. This book examines these specialized tanks, charting the development of tank craft throughout the twentieth century to better understand how aquarium modeling has enhanced our knowledge of the ...
Patients often are asked to fill out questionnaires before or after going to the doctor's office or hospital. What is the point of these questionnaires? Why do the questions often seem irrelevant? Does it matter if patients fill them out or ignore them? This book addresses these questions while also providing historical context about how these questionnaires became so popular. These questionnaires, which philosopher Leah M. McClimans calls 'Patient-Centered Measures' have a fascinating history that combines the contemporary emphasis in medical ethics on patient-centered care with the contemporary preoccupation with evidence-based medicine (the idea that medical decisions should be based on empirical evidence). Patient-centered measures sit between these two concerns and thus serve as an excellent example of a medical technology for the twenty-first century.
This book develops a systematic approach to the role of failure in innovation, using the laboratory notebooks of America's most successful inventor, Thomas Edison. It argues that Edison's active pursuit of failure and innovative uses of failure as a tool were crucial to his success. From this the author argues that not only should we expect innovations to fail but that there are good reasons to want them to fail. Using Edison's laboratory notebooks, written as he worked and before he knew the outcome we see the many false starts, wrong directions and failures that he worked through on his way to producing revolutionary inventions. While Edison's strengths in exploiting failure made him the icon of American inventors, they could also be liabilities when he moved from one field to another. Not only is this book of value to readers with an interest in the history of technology and American invention, its insights are important to those who seek to innovate and to those who employ and finance them.
A presentation of the history and philosophy of chemistry. It introduces the reader to various themes in the domain, and argues for a thesis: chemistry is not reducible to physics, but rather needs it own philosophy that reflects its practical engagement with the material world.
In scholarly debates, as well as in everyday parlance, we tend to pull science and technology apart: science gives us theory, and technology applies it. In practice, however, science and technologies are highly intertwined. In Techno-Scientific Practices: An Informational Approach, Federica Russo looks at the practice of science and elucidates the role of technologies and instruments in the process of knowledge production. In this exercise, it becomes evident that technologies cannot be analyzed on their own, but always in relation to epistemic agents. Thus, Techno-Scientific Practices emphasizes the importance of analyzing the process of knowledge production in techno-scientific contexts, in which there is a triad of relations to look at: us, the instruments, and the world. The book thus builds bridges between the philosophy of science, philosophy of technology, and science and technology studies in an unprecedent way.