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Computational Approaches for Identifying Drugs Against Alzheimer's Disease
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
Computational Approaches for Identifying Drugs Against Alzheimer's Disease
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
Therapeutic Use of Plant Secondary Metabolites
The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of diabetes, cancer, neurodegenerative disorders, and microbial infections. The 15 chapters in the book are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plant sources. Therapeutic Uses of Plant Secondary Metabolites is a timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.
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Radha
The story of Radha and Krishna offers a kaleidoscopic view of love-from the sensual to the spiritual. From this rich matrix, not only have artists, poets, saints, and religious cults drawn sustenance, but it has nurtured the mind of an entire subcontinent. In a predominantly patriarchal society where moral codes are laid out in terms of family and social responsibilities, the love between Radha and Krishna offers a delightful counterview. Here's Radha, a married woman elder to Krishna, spellbound by his charms, running to the forest on a full moon autumnal night of Sharad Purnima. To make this even more scandalous, he is sporting with other Gopis, quenching the thirst of all like undiscrimin...
Moments of Rupture: The Importance of Affect in Medical Education and Surgical Training
Surgery is a craft specialty: ‘doing’ in response to what is seen, felt and anticipated. The potent odours and the raw images of flesh, elicit strong sensations and responses in the here-and-now or ‘thisness’ (haecceities) of practice. These experiences, trigger a world of affects and senses that can disturb or rupture familiar or established ways of thinking and knowing. This book attempts to articulate these emotional complexities of learning and practice by exploring affective encounters with the uncertainty of medical events. Employing a practice based inquiry, grounded in philosophical notions of affect and related concepts, real stories of actual practice are analysed and theor...
Radha Diary of a Woman's Search
Biographically account of a Western woman's spiritual journey. Swami Radha describes her doubts, fears and challenges during her time in India with her teacher.
