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Down Syndrome: From Understanding the Neurobiology to Therapy
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brai...
Somutun Diyalektiği
Somutun Diyalektiği, 1960’lı yılların başındaki ilk basımından bu yana başta Avrupa olmak üzere tüm dünyada tartışmalara konu olmuş, eşsiz bir felsefi metindir. Kitap, temel Marksist kavramları; eleştirel bir varoluşçuluk, sistem kuramı, fenomenoloji, eleştirel kuram ve “ortodoks” Marksizm okumasıyla yeniden irdeliyor. Kitabı “somut bütünün diyalektiği” tartışmasıyla açan Kosík, bir pozitivizm, fenomenal ampirizm ve “metafizik” akılcılık eleştirisi geliştiriyor; bunların karşısına “diyalektik akılcılığı” koyuyor. Özne-nesne ilişkisinden hareketle Marksist bilim felsefesini tartışıyor; “insan ve şey” diyalektiğinden praksis, tarih, özgürlük kategorilerine uzanıyor. Bu irdeleme, “Marx ve Lukács’ın erken dönem çalışmalarından beri erişilememiş nitelikte bir fenomenolojik Marksizm”le (Paul Piccone) taçlanıyor. Somutun Diyalektiği, gerek Marksizm ve felsefe ilişkisine, gerekse de modern felsefenin en merkezî sorunlarının altında yatan yöntemsel tartışmalara meraklı okurlar için eşsiz bir kaynak niteliğinde.
The Mammoth Book of Tattoos
It is now estimated that as much as 10% of the population in the UK and USA carries a tattoo. The huge recent growth in tattoo culture has in turn led to an influx of new talented artists, advancements in pigments and refinement of the equipment used. This giant volume includes the very best of the new work made possible by modern improvements in tattoo art. Here are 500 striking photographic images of tattoos, covering all styles from bold 'tribal' pieces, Chinese characters and hieroglyphs to delicate air-brushed designs, and from all-over 'body suits' to individual motifs - works as distinctive as the bodies they adorn. Featuring the work of the Discovery Channel's L.A. Ink stars Corey Miller, Kim Saigh and Hannah Aitchinson, and London Ink's Nicole Lowe, Louis Molloy and Phil Kyle amongst many others.
The Art of Assassin's Creed Odyssey
Discover the art of Ubisoft's Assassin's Creed® Odyssey in this exclusive collection. The Art of Assassin's Creed Odyssey features concept sketches, texture studies, character art from the game, plus insightful commentary from the creators. The newest game in the franchise, Assassin's Creed® Odyssey, takes players on an epic voyage through history. The Art of Assassin's Creed Odyssey collates hundreds of concept arts, including sketches, final paintings, and 3D renders, alongside in-depth commentary from the artists and developers, representing the ultimate insight into the design processes behind the game. © 2017 Ubisoft Entertainment. All Rights Reserved. Assassin's Creed, Ubisoft, and the Ubisoft logo are trademarks of Ubisoft Entertainment in the US and/or other countries.
The Art of the Uncharted Trilogy
Adventure alongside Nathan Drake, as Dark Horse Books and Naughty Dog team up to bring you this breathtaking, comprehensive exploration into the Uncharted saga! Encompassing Drake's Fortune, Among Thieves, and Drake's Deception, this epic volume offers a look at hundreds of never-before-seen designs and pieces of concept art from the creation of one of the most exciting game series of this generation, along with insightful commentary from the games' creators! Don't miss out on this opportunity to own a piece of Uncharted history!
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The Art of Uncharted 4: A Thief's End
Journey alongside Nathan Drake once again, as Naughty Dog and Dark Horse Books team up to bring you this comprehensive and breathtaking exploration into Uncharted 4: A Thief's End! Numerous never-before-seen designs and concept art accompanied by commentary from the developers give you behind-the-scenes access to the creation of this gaming masterwork. This beautiful oversized hardcover is a must-have for any fan of the Uncharted franchise and high quality video game art. The Art of Unchartend 4 will be released by Dark Horse simultaneoulsy with the new game, Uncharted 4.
Kate
Kate Moss is one of the newest of the supermodels. Her unique look has inspired top photographers, including Stephen Meisel, Bruce Weber, Herb Ritts, Helmut Newton and Richard Avedon, top fashion editors and top fashion designers, particularly Calvin Klein.
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