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Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry
This book covers the state-of-the-art of modern MALDI (matrix-assisted laser desorption/ionization) and its applications. New applications and improvements in the MALDI field such as biotyping, clinical diagnosis, forensic imaging, and ESI-like ion production are covered in detail. Additional topics include MS imaging, biotyping/speciation and large-scale, high-speed MS sample profiling, new methods based on MALDI or MALDI-like sample preparations, and the advantages of ESI to MALDI MS analysis. This is an ideal book for graduate students and researchers in the field of bioanalytical sciences. This book also: • Showcases new techniques and applications in MALDI MS • Demonstrates how MALDI is preferable to ESI (electrospray ionization) • Illustrates the pros and cons associated with biomarker discovery studies in clinical proteomics and the various application areas, such as cancer proteomics
Artificial Intelligence Applications and Innovations
This book constitutes the refereed proceedings of the Workshops held at the 8th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2012, in Halkidiki, Greece, in September 2012. The book includes a total of 66 interesting and innovative research papers from the following 8 workshops: the Second Artificial Intelligence Applications in Biomedicine Workshop (AIAB 2012), the First AI in Education Workshop: Innovations and Applications (AIeIA 2012), the Second International Workshop on Computational Intelligence in Software Engineering (CISE 2012), the First Conformal Prediction and Its Applications Workshop (COPA 2012), the First Intelligent Innovative Ways for Video-to-Video Communiccation in Modern Smart Cities Workshop (IIVC 2012), the Third Intelligent Systems for Quality of Life Information Services Workshop (ISQL 2012), the First Mining Humanistic Data Workshop (MHDW 2012), and the First Workshop on Algorithms for Data and Text Mining in Bioinformatics (WADTMB 2012).
Hypertension
A collection of new and essential molecular techniques for cardiovascular research. These readily reproducible methods range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using nonviral (polymers, liposomes, and antisense agents) and adenoviral vectors. Additional techniques described include single nucleotide polymorphism (SNP) genotyping, RNA interference, microarray analysis, pharmacogenetics, and pharmacogenomics for the genetic dissection of hypertension, as well as a practical method for deriving cardiomyocytes from embryonic stem cells that would serve as replacement cells for those damaged by hypertension or heart attack. The book offers both novice and experienced hypertension researchers an indispensable collection of readily reproducible techniques for successful research, work that has already dramatically improved the outlook for hypertensive patients, and promises much future success.
Protein'Protein Interactions
As the mysteries stored in our DNA have been more completely revealed, scientists have begun to face the extraordinary challenge of unraveling the int- cate network of protein–protein interactions established by that DNA fra- work. It is increasingly clear that proteins continuously interact with one another in a highly regulated fashion to determine cell fate, such as proliferation, diff- entiation, or death. These protein–protein interactions enable and exert str- gent control over DNA replication, RNA transcription, protein translation, macromolecular assembly and degradation, and signal transduction; essentially all cellular functions involve protein–protein interactions. Thus, pro...
Biofungicides: Eco-Safety and Future Trends
The current volume focuses on novel sources of biofungicides, primarily providing complete knowledge of microbial and phytochemical fungicides, studying antifungal activity mechanisms as well as their role in disease management in plants, and fungicide bioremediation. The use of biofungicides as eco-friendly alternative to typical synthetic fungicides is projected to play a significant role in organic farming in the future. Key Features: Discovers novel sources of biofungicides Describes the role of biofungicides in the control of plant diseases Studies antifungal activity mechanisms Explores how to survey and select promising biofungicides
Artificial Intelligence Applications and Innovations
The abundance of information and increase in computing power currently enable researchers to tackle highly complicated and challenging computational problems. Solutions to such problems are now feasible using advances and innovations from the area of Artificial Intelligence. The general focus of the AIAI conference is to provide insights on how Artificial Intelligence may be applied in real-world situations and serve the study, analysis and modeling of theoretical and practical issues. This volume contains papers selected for presentation at the 6th IFIP Conference on Artificial Intelligence Applications and Innovations (AIAI 2010) and held in Larnaca, Cyprus, during October 6–7, 2010. IFI...
Experimental Organic Chemistry
The definitive guide to the principles and practice of experimental organic chemistry - fully updated and now featuring more than 100 experiments The latest edition of this popular guide to experimental organic chemistry takes students from their first day in the laboratory right through to complex research procedures. All sections have been updated to reflect new techniques, equipment and technologies, and the text has been revised with an even sharper focus on practical skills and procedures. The first half of the book is devoted to safe laboratory practice as well as purification and analytical techniques; particularly spectroscopic analysis. The second half contains step-by-step experime...
Prostate Cancer Methods and Protocols
Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why certain prostate cancers remain localized or indolent, whereas others become aggressive and metastasize. The differences between these cancer types have profound implications for patients and physicians. Indolent d- ease, which grows very slowly, generally does not cause any problems to the patient, whereas aggressive disease requires immediate treatment, the earlier the better. At present, there are no markers that discriminate between these two entities, thus causing a dilemma for the management of patients who have recently been diagnosed. ...
Sample Preparation in Biological Mass Spectrometry
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
