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Current Catalog
First multi-year cumulation covers six years: 1965-70.
Circumventricular Organs and Brain Fluid Environment
This volume provides a picture of the state of the art and of the perspectives opened by new powerful approaches to the study of the structure and function of Circumventricular Organs (CVOs). Studies on the CVOs reflected in this book comprise many aspects, from cellular elements to the whole organism: the accessibility of these organs for chemical signals, signal (ligand)-receptor interactions, the transfer of information to distinct brain regions, the effects induced in these brain regions and the influence on the regulation of body functions including autonomic and behavioral alterations. Some of these aspects strongly depend upon the microenvironment of the cells involved in this cascade of events. Therefore, the brain fluid environment in its broadest sense is a central focus. This excellent work is therefore an up-to-date report on interdisciplinary approaches and concepts, offering new insights into the complex phenomena of brain function, and shows directions in which to proceed."
Integrative and Cellular Aspects of Autonomic Functions
Proceedings of the International Symposium on Integrative and Cellular Aspects of Autonomic Functions Held in Bad Nauheim (Germany) on 29-30 July 1993.
The Heart of the Brain
How hormonal signals in one small structure of the brain—the hypothalamus—govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain—the hypothalamus—influences what we do, how we love, and who we are. The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
Our Most Troubling Madness
Schizophrenia has long puzzled researchers in the fields of psychiatric medicine and anthropology. Why is it that the rates of developing schizophrenia—long the poster child for the biomedical model of psychiatric illness—are low in some countries and higher in others? And why do migrants to Western countries find that they are at higher risk for this disease after they arrive? T. M. Luhrmann and Jocelyn Marrow argue that the root causes of schizophrenia are not only biological, but also sociocultural. This book gives an intimate, personal account of those living with serious psychotic disorder in the United States, India, Africa, and Southeast Asia. It introduces the notion that social defeat—the physical or symbolic defeat of one person by another—is a core mechanism in the increased risk for psychotic illness. Furthermore, “care-as-usual” treatment as it occurs in the United States actually increases the likelihood of social defeat, while “care-as-usual” treatment in a country like India diminishes it.
Developmental Neuroendocrinology
In this book, experts in the field discuss the latest research in developmental neuroendocrinology. Given that the hypothalamus is the center of neuroendocrine activity, the reader will learn about the molecular specification of hypothalamic cells, developmental modulators and epigenetic factors influencing hypothalamic development, and the development of neuroendocrine circuits. Each chapter provides a concise review of the current and future perspectives in developmental neuroendocrinology. Important insights into state-of-the-art techniques applied to functional circuit tracking, lineage tracing of hypothalamic cells, and the identification of genes altered through epigenetic mechanisms a...
Charney & Nestler's Neurobiology of Mental Illness
In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology...
Neurophysiology of Neuroendocrine Neurons
Neurophysiology of Neuroendocrine Neurons provides researchers and students with not only an understanding of neuroendocrine cell electrophysiology, but also an appreciation of how this model system affords access to virtually all parts of the neuron for detailed study - something unique compared to most types of neuron in the brain. Chapters range from those describing the rich history and current state of in vivo recordings, highlighting the precise relationship between the patterns of action potential discharge in these neurons and hormone release, to in vitro approaches where neuroendocrine neurons can be precisely identified and their membrane properties, morphology, and synaptic respon...
Biomarkers for Psychiatric Disorders
Biomarkers hold immense promise for the early detection of disease. Unlike other disorders like diabetes and heart disease where a limited number of biological markers are at hand that allow the physician to come up with a reliable diagnosis, there are currently no such markers available for affective disorders. As in any other disease area a major goal is therefore the identification of early markers that can categorize subsets of subjects in a consistent manner. This will allow a more precise definition and categorization of affective disorders and in turn facilitate investigations of the pathogenesis of the diseases and enhance our ability for treatment. This edited volume will not only address the area of affective disorders but also other brain disorders that are neurological in nature, including Multiple Sclerosis and Alzheimer Disease.
