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Synthesis and Analytics of Rigidified Peptide Architectures. Neuropeptide Y Dipeptide Scan Ring-Chain-Equilibria of Iminopeptides Thiazole Amino Acids for Thiopeptide Antibiotics
The architectures (three-dimensional shapes) of peptides determine their respective biological functions. Therefore, the correct alignment of functionalities in a structure by constraining the flexibility is a key process in evolution as well as in medicinal chemistry in order to increase binding affinity and selectivity. The rigidification of a peptide chain can have local effects (incorporation of the amino acid proline) or it can globally restrain flexibility (macrocyclization). Furthermore, the combination of both strategies has given rise to complex antibiotics with highly optimized modes of action. This work approaches these principles in three topics and for different purposes. The fi...
Statement of Disbursements of the House
Covers receipts and expenditures of appropriations and other funds.
Michiganensian
None
Imaging from Cells to Animals In Vivo
Imaging from Cells to Animals In Vivo offers an overview of optical imaging techniques developed over the past two decades to investigate biological processes in live cells and tissues. It comprehensively covers the main imaging approaches used as well as the application of those techniques to biological investigations in preclinical models. Among the areas covered are cell metabolism, receptor-ligand interactions, membrane trafficking, cell signaling, cell migration, cell adhesion, cytoskeleton and other processes using various molecular optical imaging techniques in living organisms, such as mice and zebrafish. Features Brings together biology and advanced optical imaging techniques to pro...
Proceedings
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Iowa City
After raucous times on the western frontier during the 1840s and 1850s, Iowa City settled into a relatively sleepy existence while its principal industry, the University of Iowa, was finding its way from obscurity into an important Iowa resource. Its once-too-small-to-succeed university hospital has blossomed into a medical and economic powerhouse. Research in widely varied fields, from space science to microbiology, finds fertile grounds and minds. Big Ten football beckons on fall Saturdays.
