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Accelerated Path to Cures
Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.
Social Factors, Health Care Inequities and Vaccination
Employing a sociological and broader social sciences approach, this volume draws on a variety of contexts, including the COVID-19 pandemic, to explore wider trends in healthcare and the impact they may have on historically disadvantaged communities.
Digital Health Transformation with Blockchain and Artificial Intelligence
The book Digital Health Transformation with Blockchain and Artificial Intelligence covers the global digital revolution in the field of healthcare sector. The population has been overcoming the COVID-19 period; therefore, we need to establish intelligent digital healthcare systems using various emerging technologies like Blockchain and Artificial Intelligence. Internet of Medical Things is the technological revolution that has included the element of "smartness" in the healthcare industry and also identifying, monitoring, and informing service providers about the patient’s clinical information with faster delivery of care services. This book highlights the important issues i.e. (a) How Int...
Catastrophic Incentives
Silver Award Winner, 2024 Nonfiction Book Awards Societies are vulnerable to any number of potential disasters: earthquakes, hurricanes, infectious diseases, terrorist attacks, and many others. Even though the dangers are often clear, there is a persistent pattern of inadequate preparation and a failure to learn from experience. Before disasters, institutions pay insufficient attention to risk; in the aftermath, even when the lack of preparation led to a flawed response, the focus shifts to patching holes instead of addressing the underlying problems. Examining twenty years of disasters from 9/11 to COVID-19, Jeff Schlegelmilch and Ellen Carlin show how flawed incentive structures make the w...
Critical Approaches to Death, Dying and Bereavement
This book is the first of its kind to examine key topics in death, dying, and bereavement through a critical lens, highlighting how the understanding and experience of death can vary considerably, based on social, cultural, historical, political, and medical contexts. It looks at the complex ways in which death and dying are managed, from the political level down to end- of- life care, and the inequalities that surround and impact experiences of death, dying, and bereavement. Readers are introduced to key theories, such as the medicalisation of dying, as well as contemporary issues, such as social movements, pandemics, and assisted dying. The book stresses how death is not only a biological ...
Molecular Diagnostics in the Detection of Neurodegenerative Disorders
Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tiss...
Non-Invasive Health Systems based on Advanced Biomedical Signal and Image Processing
This book contains up-to-date noninvasive monitoring and diagnosing systems closely developed by a set of scientists, engineers, and physicians. The chapters are the results of different biomedical projects and theoretical studies that were coupled by simulations and real-world data. Non-Invasive Health Systems based on Advanced Biomedical Signal and Image Processing provides a multifaceted view of various biomedical and clinical approaches to health monitoring systems. The authors introduce advanced signal- and image-processing techniques as well as other noninvasive monitoring and diagnostic systems such as inertial sensors in wearable devices and novel algorithm-based hybrid learning syst...
Individual’s Mechanics, Movement and Kinematics Post-Stroke
Disability after stroke is a major burden on society, due to its high incidence and prevalence. Among the priorities of rehabilitation programs, stroke rehabilitation aims to regain independence and improve patients’ quality of life. Dynamic balance, falls prevention and upper limb recovery are essential features for the clinical management of hemiparetic patients. To optimize movement recovery after stroke, it is essential to select multilevel outcome measures for interpretation of motor recovery and clinical decision-making. In this context, the assessment of movement by means of quantitative movement analysis in hemiparetic post-stroke patients is key to planning rehabilitative intervention. Kinematic analysis facilitates interpreting the extent and mechanisms of motor restoration, and it has been increasingly applied in neurological research.
