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Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. - Unique for its treatment of platform technologies for medicinal chemistry and target validation - Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field - Presents state-of-the-art summaries of platform technologies
This book provides a compelling overall update on current status of RNA interference
Lists for 19 include the Mathematical Association of America, and 1955- also the Society for Industrial and Applied Mathematics.
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.
Preliminary facts Basic concepts of scattering theory Further properties of the WO Scattering for relatively smooth perturbations The general setup in stationary scattering theory Scattering for perturbations of trace class type Properties of the scattering matrix (SM) The spectral shift function (SSF) and the trace formula
This book covers analysis on fractals, a developing area of mathematics which focuses on the dynamical aspects of fractals, such as heat diffusion on fractals and the vibration of a material with fractal structure. The book provides a self-contained introduction to the subject, starting from the basic geometry of self-similar sets and going on to discuss recent results, including the properties of eigenvalues and eigenfunctions of the Laplacians, and the asymptotical behaviors of heat kernels on self-similar sets. Requiring only a basic knowledge of advanced analysis, general topology and measure theory, this book will be of value to graduate students and researchers in analysis and probability theory. It will also be useful as a supplementary text for graduate courses covering fractals.