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Progress in Drug Research
S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture.
Neurobiology of Depression
Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as...
Neuroregulation of Autonomic, Endocrine and Immune Systems
Our understanding of the functioning of the brain has grown rapidly over the last decade or two. So has our recognition of the possible role of brain dysfunction in diseases considered earlier to be of peripheral or somatic origin. This culminates naturally in a focus on the nature of the influence of the brain on other systems such as the autonomic, neuroendocrine and immune systems. And we must come full circle and question the nature of the influence of these systems on the function of the brain. Thus, we gain a picture of a complex regulatory interaction, fine tuned in normal circumstances to provide each system with necessary information about the status of the other systems and the bas...
Drug Discovery and Development
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of huma...
Journal of the National Cancer Institute
Each issue is packed with extensive news about important cancer related science, policy, politics and people. Plus, there are editorials and reviews by experts in the field, book reviews, and commentary on timely topics.
Neurochemistry in Clinical Application
Neurological disorders cause untold suffering and financial burden to hundreds of thousands of people, not only to the patients, but also the relatives and society. As of today, though numerous scientists and clinicians have devoted their efforts to understand and combat these diseases, there is still no cure or satisfactory solution to the problems. Furthermore, the brain is the most essential organ of a human being. Realizing the importance of the brain, the president of the United States, George Bush, declared the 90s as the Decade of the Brain in January, 1992. Being in neuroscience research for almost three decades, I initiated, planned and organized the first international neuropharmac...
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Volume 40 of "Progress in Drug Research" contains six reviews and the various indexes which facilitate its use and establish the connec tion with the previous volumes. The articles in this volume deal with phosphodiesterase inhibitors and their therapeutic potential in asthma; peptide receptor ligand drugs; aldose reductase inhibitors; the design and discovery of new drugs by stepping-down and stepping-up approaches; new synthetic ligands for L-type voltage gated calcium channels and with luteolytic agents in fertility regula tion. III the 33 years that "Progress in Drug Research" has existed, the Edi tor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the review ers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.
