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This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.
Diabetes has reached epidemic proportions, and the cardiovascular complications of diabetes are life-threatening and disabling. This book is unique in providing a simple explanation of the biochemical role of PKC in diabetes complications, which allows clinicians to understand why PKC inhibitors (in development) are an exciting prospect for future treatment to slow progression of eye & foot complications. New features of this Second Edition include: Updated throughout to reflect the impact of recent major clinical trials on current clinical practice Includes a major new section on diabetic neuropathy Revised section on diabetic retinopathy Each chapter is short and succinct, focusing on ‘best practice’. There are key learning points at the end of each chapter, with numerous helpful tables, figures and clinical images.
The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic re...
Preceded by Textbook of diabetes / edited by Richard I.G. Holt ... [et al.]. 4th ed. 2010.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors. - Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
This volume of International Review of Neurobiology defines primary biochemical causation of diabetic complications, identifies cellular glucose transducers, balancing roles of protein kinase C and MAP kinases, and sets in context the role of apoptosis and the interactive roles of neurons and Schwann cells. It also defines the cell biology of autonomic neuropathy, considers the balanced needs of science, clinical practice, and economics in clinical trial design, provides the definitive evaluation of aldose reductase inhibitors, and explains the failure of nerve growth factor. One of the most successful series in the field of neuroscience continues its standard of excellence with this newest edition. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists.
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on ...
The book is designed for end users in the field of digital imaging, who wish to update their skills and understanding with the latest techniques in image analysis. The book emphasizes the conceptual framework of image analysis and the effective use of image processing tools. It uses applications in a variety of fields to demonstrate and consolidate both specific and general concepts, and to build intuition, insight and understanding. Although the chapters are essentially self-contained they reference other chapters to form an integrated whole. Each chapter employs a pedagogical approach to ensure conceptual learning before introducing specific techniques and “tricks of the trade”. The bo...
Diabetes Digital Health, Telehealth, and Artificial Intelligence explains how to develop and use the emerging technologies of digital health, telehealth, and artificial intelligence to address this important public health problem to deliver new hardware, software, and processes. The book explores trends in developing and deploying the three most important emerging technologies for diabetes: digital health, telehealth, and artificial intelligence. This book is essential to clinicians, scientists, engineers, industry professionals, regulators, and investors, offering the tools that will be used to create the next generation products to support a precision medicine approach to manage diabetes. ...