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The RNA World
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Recoding: Expansion of Decoding Rules Enriches Gene Expression
The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solv...
The Origin and Nature of Life on Earth
Uniting the foundations of physics and biology, this groundbreaking multidisciplinary and integrative book explores life as a planetary process.
Human Genome
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Pacific Symposium on Biocomputing 2002, Kauai, Hawaii, 3-7 January 2002
The Pacific Symposium on Biocomputing brings together key researchers from the international biocomputing community. It is designed to be maximally responsive to the need for critical mass in subdisciplines within biocomputing. This book contains peer-reviewed articles in computational biology. Contents: Human Genome Variation: Disease, Drug Response, and Clinical Phenotypes; Genome-Wide Analysis and Comparative Genomics; Expanding Proteomics to Glycobiology; Literature Data Mining for Biology; Genome, Pathway and Interaction Bioinformatics; Phylogenetic Genomics and Genomic Phylogenetics; Proteins: Structure, Function and Evolution. Readership: Graduate students, academics and industrialists in bioinformatics.
Evolutionary Dynamics
The 14 chapters of this volume, which present an overview of new research in evolutionary dynamics, were first presented at a conference held in October 1998 at the Santa Fe Institute. The main divisions of the book are macroevolution; epochal evolution; population genetics, dynamics, and optimization; and evolution of cooperation. Individual topics include spectral landscape theory, external triggers in biological evolution, and evolutionary dynamics of asexual reproduction. Several of the contributors, like the editors, are affiliated with the Sante Fe Institute; others teach or work in physics, genetics, biology, computational neuroscience, and theoretical chemistry at universities and private institutions in the US, UK, Austria, Sweden, Australia, Israel, and Germany. Annotation copyrighted by Book News, Inc., Portland, OR
Research Grants
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Regulatory RNAs
Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory...
