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Immune Checkpoint Inhibitors
Immune Checkpoint Inhibitors - New Insights and Recent Progress explores a vast array of subjects related to immune checkpoint inhibitors and presents novel insights in this emerging field. Chapters address such topics as mechanistic approaches of emerging immune checkpoint inhibitors, their role in clinical and pre-clinical trials, the manipulation of the system by immune-related adverse events that hinder the utility of these immune molecules, and the predictive and prognostic aspects of these molecules as biomarkers of response in immunotherapy. The book is useful for students, clinicians, and scientists to gain updated information on managing patients treated with immune checkpoint inhibitors.
Precision Vaccinology for Infectious Diseases
The Human body is a vast network of interacting genes, proteins, and metabolites. These components, which may be considered host factors, change under disease, treatment or healthy condition. While treatment of many diseases depends on therapeutic drugs, vaccines remain the most effective long-term public health intervention to prevent infectious diseases. To date, vaccines have been developed to treat entire populations with little provision for predisposing individual host factor differences. However, the use and application of vaccines is facing multiple challenges with increasing numbers of vaccine non-responders and vaccine-relapsed individuals. The cause of this complication is partially due to host-factors. Another challenge is the adverse effects of vaccines in patients with primary immunodeficiency or autoimmune diseases, as well as vaccine-waning immunity in ageing populations, obese populations, or those with co-infection. To overcome these challenges, the solution may be the design, and formulation of precision vaccines, which are patient-specific.
Novel biomarkers in tumor immunity and immunotherapy
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there...
Supporting Environmental Stability Through Ecotourism
Leisure travel is more widespread and accessible than ever before, but the world faces the growing problem of its unintended consequences. The desire to explore the globe has led to an increase in tourism, with billions of individuals traveling to various destinations, fueling economic growth and infrastructure development. However, it has brought forth many challenges that demand our attention, including the unsustainable consumption of energy, environmental degradation, climate change, and the excessive cost of maintaining tourist hotspots. The high influx of visitors to many destinations has left more than just a negative imprint upon nature, it has also disrupted the daily lives and live...
Infectious Agents in Ophthalmology: Clinical Perspectives
"This book, "Infectious Agents in Ophthalmology: Clinical Perspectives," will serves as a timely and essential resource for both clinicians and medical student, It compiles the latest insights and findings on various infectious agents, ranging from bacteria and viruses to fungi and parasites, each of which poses unique challenges in diagnosis and management. The contributions from esteemed experts in the field offer a comprehensive overview. The integration of clinical perspectives throughout thee chapters not only enhances our understanding of these infections but also emphasizes the importance of a multidisciplinary approach in managing patients. The book highlights the need for vigilance, timely intervention, and the application of emerging technologies in diagnosis and treatment, ensuring that we are well-equipped to tackle the evolving landscape of Ophthalmology infections.
Proceedings of the 11th International Conference on Robotics, Vision, Signal Processing and Power Applications
The proceeding is a collection of research papers presented at the 11th International Conference on Robotics, Vision, Signal Processing & Power Applications (RoViSP 2021). The theme of RoViSP 2021 “Enhancing Research and Innovation through the Fourth Industrial Revolution (IR 4.0)” served as a platform for researchers, scientists, engineers, academicians as well as industrial professionals from all around the globe to present and exchange their research findings and development activities through oral presentations. The book covers various topics of interest, including: Robotics, Control, Mechatronics and Automation Telecommunication Systems and Applications Electronic Design and Applications Vision, Image and Signal Processing Electrical Power, Energy and Industrial Applications Computer and Information Technology Biomedical Engineering and Applications Intelligent Systems Internet-of-things Mechatronics Mobile Technology
