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Endothelin in Renal Physiology and Disease
A comprehensive reference book on basic and clinical aspects Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biolog...
Handbook of Sepsis
This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Behavior Management in Dentistry for Children
Guiding patient behavior is as important as ever for the practicing dentist, and the behavior of pediatric patients is perhaps the most challenging to manage. Drs. Wright and Kupietzky here update Dr. Wright’s classic work on managing pediatric dental patients. Behavior Management in Dentistry for Children,2nd Edition, has been entirely rewritten and includes the latest and most effective management strategies from an international team of experts in the field. The book addresses the influence of family and parenting styles on children’s behavior and the factors that determine how children behave in the dental office. Pharmacological and non-pharmacological management techniques are desc...
Monoaminergic Modulation of Cortical Excitability
This book provides a comprehensive, integrated comparison of the complex modulatory action of dopamine, noradrenaline, and serotonin receptors in the cortex. The discussion assembles a range of opinions on how the monoamine systems affect cortical function. The complexity of these interactions is discussed in light of recent data showing the dramatic effect of disruption of these systems on memory formation and information processing in the cortex.
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands
T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 o...
