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mRNA Processing and Metabolism
Cells possess a wealth of posttranscriptional control mechanisms that impact on every conceivable aspect of the life of an mRNA. These processes are intimately intertwined in an almost baroque manner, where promoter context influences the recruitment of splicing factors, where the majority of pre-mRNAs undergo alternative splicing, and where proteins deposited during nuclear processing impact distal cytoplasmic processing, translation, and decay. If there is a unifying theme to mRNA Processing and Metabolism: Methods and Protocols, it is that mRNA processing and metabolism are integrated processes. Many of the techniques used to study mRNA have been described in a previous volume of this ser...
RNP Particles, Splicing and Autoimmune Diseases
The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles. Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.
Biochemistry Max Planck Institute
Max Planck Institute of Biochemistry-An introduction to the pioneering work conducted at the Max Planck Institute of Biochemistry, this chapter highlights its global role in biochemistry research Protein-Explores the fundamental role of proteins in cellular functions, providing key insights into their structure, function, and interaction Structural biology-Discusses the methods and significance of determining the 3D structures of biomolecules, essential for understanding biological systems Max Planck Institute for Biophysical Chemistry-Focuses on the innovative research conducted at the Institute, showcasing its impact on biophysical chemistry and molecular biophysics Patrick Cramer-Presents...
Biophysical Chemistry Max Planck Institute
Unlock the fascinating world of biophysical chemistry and gain insight into the cuttingedge research conducted at the prestigious Max Planck Institutes. "Biophysical Chemistry Max Planck Institute," part of the "Molecular Biophysics" series, offers a comprehensive exploration of biophysical chemistry, from historical milestones to contemporary advancements. Whether you're a professional, an undergraduate, a graduate student, or simply an enthusiast of molecular biophysics, this book provides invaluable knowledge that bridges the gap between science and practical application Chapters Brief Overview: Max Planck Institute for Biophysical Chemistry: The foundation of biophysical chemistry at the...
20. Jahrestagung der Deutschen Gesellschaft für Kristallographie; March 2012, Munich, Germany
Zeitschrift für Kristallographie. Supplement Volume 32 presents the complete Abstracts of all contributions to the 20th Annual Conference of the German Crystallographic Society in Munich 2012: - Plenary Talks - Microsymposia - Poster Session Supplement Series of Zeitschrift für Kristallographie publishes Proceedings and Abstracts of international conferences on the interdisciplinary field of crystallography.
Molecular Biophysics
In an everevolving world where molecular science and biophysics converge, "Molecular Biophysics" offers an essential exploration into the intricate mechanisms that shape biological systems at a molecular level. This book is a vital resource for professionals, students, and enthusiasts alike, providing profound insights into the fundamental principles driving molecular interactions. By uncovering the layers of protein structure, folding, and biophysics, the book connects scientific theory to realworld applications in areas like biotechnology and medical research. Chapters Brief Overview: 1: Molecular biophysics: Introduction to the core principles and relevance of molecular biophysics. 2: Alp...
Recent Advances In Molecular And Biochemical Research On Proteins - Proceedings Of The Iubmb Symposium On Protein Structure And Function
This monograph is edited on the basis of the lecture contents of invited speakers and some oral presentations at the IUBMB Symposium on Protein Structure and Function. The main theme was the molecular and biochemical studies on the structure and function of proteins. It covers the most recent advances in research on animal and bacterial toxins, plant enzymes and proteins, structural motifs and functional aspects of enzymes, biophysical and chemical characterizations of snake toxins by NMR spectroscopy, and molecular approaches for studying the structure-function relationship of proteins and enzymes. Most of the papers are based on data obtained in the authors' laboratory over the past few years and were written in a concise manner as review articles. They will be valuable reference for researchers and graduate students in this field of study.
RNA'Protein Interaction Protocols
The molecular characterization of RNA and its interactions with proteins is an important and exciting area of current research. Organisms utilize a variety of RNA–protein interactions to regulate the expression of their genes. This is particularly true for eukaryotes, since newly synthesized messenger RNA must be extensively modified and transported to the cytoplasm before it can be used for protein synthesis. The realization that posttranscriptional processes are critical components of gene regulation has sparked an explosion of interest in both stable ribonucleoprotein (RNP) complexes and transient RNA–protein interactions. RNA is conformationally flexible and can adopt complex structu...
Handbook of RNA Biochemistry
The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.
Alternative pre-mRNA Splicing
Der definitive Leitfaden zum RNA-Splicing - ideal für alle Kliniker, die sich mit genetischen Erkrankungen befassen, insbesondere natürlich für RNA-Forscher. Website: www.wiley-vch.de/home/splicing
