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Clinical Trials Handbook
Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every...
Kidney Transplantation
This publication reviews the immunology of transplant rejection as the basis for modern immunosupression protocols. It also looks at the current criteria for selection of kidney transplant recipients and donors.
Genetics for Pulmonologists
Our understanding of the relationship between genetics and pulmonary disorders is still evolving. In 1989 cloning of the gene that, when mutated, causes cystic fibrosis marked a great advance in the study of genetic diseases. Yet, over a decade later, understanding of how this genetic defect leads to colonization by bacteria and inflammation in the lung remains elusive.
The Handbook of Diabetes Mellitus and Cardiovascular Disease
Annotation Interventional cardiologists, general cardiologists, endocrinologists, diabetologists The World Health Organization has projected that the prevalence of diabetes will double over the next 22 years - from a current figure of 150 million to an estimated 300 million people by the year 2025. The health-care burden of diabetes is enormous, and effective strategies to combat the explosive rise in the global incidence and prevalence of diabetes are urgently needed. Furthermore, diabetic patients have a considerable risk for cardiovascular disease, with up to 80% of deaths in individuals with diabetes attributable to microvascular or macrovascular complications. This book provides a concise overview of the present state of the art relating to the impact of diabetes mellitus on cardiovascular disease and to emerging treatment strategies that are beginning to impact on the management of the cardiovascular complications of this debilitating condition.
Anal and Rectal Diseases Explained
This work examines rectal and perianal complaints. It covers the variety of techniques, such as endoscopic ultrasound and magnetic resonance imaging, employed for the evaluation of these disorders. As well as new pharmacotherapies, topical therapies and new surgical treatments.
Imaging in Stroke
Neuroimaging techniques are crucial in the management of stroke patients. This book is an important resource in the quest to better understand stroke and its heterogeneity. After a first chapter on the classification of stroke, it outlines that neuroimaging techniques are not only useful to diagnose stroke, its mechanisms, and its causes, but are also an important tool to improve our knowledge on the pathophysiology of stroke and of its recovery. This book has involved prestigious contributors who have a great knowledge on this topic, and are skilled at describing the current state of knowledge, and also at projecting developments that are likely to occur in the future. This book is useful for all those who have to manage stroke patients at the acute stage, or later, and for those who are in search of a focused, authoritative review on this subject. It will assume a prominent place as a reference.
Brain Imaging in Epilepsy
Recent advances in functional neuroimaging have greatly enhanced our understanding of brain functionality through the ability to visualize brain processes at work. Brain Imaging in Epilepsy provides an overview of the techniques that have been developed, including positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), diffusion weighted imaging (DWI) and magnetic resonance spectroscopy (MRS). Relevant features of the basic neuroscience of epilepsy are reviewed, and the application of these techniques in diagnosing, treating and developing new treatments for epilepsy is discussed. This book will prove fascinating to a large audience from practicing neurologists and radiologists, to junior doctors and students of medicine, neuroscience and medical physics.
Multiple Myeloma
Multiple myeloma is the second most common hematologic malignancy, affecting 15,000 patients per year in the United States. Despite the advent of high-dose chemotherapy with stem cell transplantation, multiple myeloma remains incurable, with approximately 12,000 deaths per annum recorded in the US from the disease. Over the last 10 years, there has been a dramatic increase in our understanding of the biology of multiple myeloma, which has provided insights into mechanisms of cytotoxic resistance, both as inherent characteristics of the myeloma cell and the protective interaction between the tumor and its bone marrow microenvironment. Moreover, advances in our understanding of multiple myeloma pathogenesis have helped further define the intricacies of this complex disease. This book provides a concise overview of the state-of-the-art in multiple myeloma and should be of primary interest to clinicians as well as scientists and related caregivers alike in this rapidly changing f.
Genetics for Rheumatologists
Annotation Trainee and practicing rheumatologists The study of disease genetics arguably began in rheumatology, with the description of the hereditary basis of alkaptonuria by Garrod in 1902, and the introduction of the concept of in-born errors of metabolism. A large proportion of the diseases seen by rheumatologists have genetic influences. The dissection of the genetic basis of rheumatic diseases has moved rapidly over the past 15 years. Increasingly, rheumatologists are being asked the question "How likely is it that my children will develop the disease I have?', and about the utility of genetic testing for those diseases. This book is not a hefty tome full of genetics jargon, but a quick reference source for doctors written to help answer those questions.
