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The calcitonin gene-related peptide family
In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower ...
Peptide Receptors
Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Transmitters and Modulators in Health and Disease
Prominent international researchers contributed to this volume of reports advancing the study of brain function and morphology. Comprising investigations in several areas of neuroscience, the book includes research in neurodegenerative diseases and in neuroregeneration in adults. Described here are the effects of neuropeptides and biogenic amines on feeding, respiration, and other autonomic functions as well as on behavior. One chapter focuses on regulation of the blood brain barrier function by various neuropeptides, proteins, receptors, and transporters. Another is concerned with the modulation of higher brain functions by neuropeptides and biogenic monoamines. Yet another chapter presents research on ischemic neuronal damage and hippocampal neurogenesis in the adult mouse. Morphological or physiological techniques to study neuropeptides and neuromodulators influencing higher-order or brain-stem functions are given particular attention. The use of bio-imaging tools such as brain navigation systems and fMRIs with patients in a clinical setting creates new possibilities for investigation of human brain function and specialization of treatment.
Substance P and Neurokinins
Sarajevo was the site of the first international meeting on substance P. It was held in 1961, thirty years after the first report of the discovery of substance P by Von Euler and Gaddum. The proceedings which follow are from a symposium held twenty-five years after the first meeting. These twenty-five years have seen a vast expansion in this field ofresearch. This family of peptides now includes a number of different mammalian and non-mammalian related peptides. Beyond the early physiological and pharmacological studies, there is important new information coming from the full spectrum of disciplines in the basic medical sciences, including molecular biology, which has given us important insi...
Cholinergic Function and Dysfunction
Presents a comprehensive update of central cholinergic mechanisms from their most molecular aspects to possible clinical applications modifying cholinergic neurotransmission. A considerable number of high-calibre scientists from several continents contributed to this volume.
Focus on Neuropsychology Research
Neuropsychology is the study of brain-behaviour relationships and examines such domains of cognitive functioning as memory, attention, visual-perceptual abilities, language and intellectual function. It is strongly scientific in its approach and shares an information processing view of the mind with cognitive psychology and cognitive science. It is one of the most eclectic of the psychological disciplines, overlapping at times with areas such as neuroscience, philosophy (particularly philosophy of mind), neurology, psychiatry and computer science (particularly by making use of artificial neural networks).
