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Tabula Raza
Duana Fullwiley has penned an intimate chronicle of laboratory life in the genomic age. She presents many of the influential scientists at the forefront of genetics who have redefined how we practice medicine and law and understand ancestry in an era of big data and waning privacy. Exceedingly relatable and human, the scientists in these pages often struggle for visibility, teeter on the tightrope of inclusion, and work tirelessly to imprint the future. As they actively imagine a more equal and just world, they often find themselves ensnared in reproducing timeworn conceits of race and racism that can seed the same health disparities they hope to resolve. Nothing dynamic can live for long as a blank slate, an innocent tabula rasa. But how the blank slate of the once-raceless human genome became one of racial differences, in various forms of what Fullwiley calls the tabula raza, has a very specific and familiar history—one that has cycled through the ages in unexpected ways.
Current Challenges in Cardiovascular Molecular Diagnostics
The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presen...
Archaeology as History
This Element volume focuses on how archaeologists construct narratives of past people and environments from the complex and fragmented archaeological record. In keeping with its position in a series of historiography, it considers how we make meaning from things and places, with an emphasis on changing practices over time and the questions archaeologists have and can ask of the archaeological record. It aims to provide readers with a reflexive and comprehensive overview of what it is that archaeologists do with the archaeological record, how that translates into specific stories or narratives about the past, and the limitations or advantages of these when trying to understand past worlds. The goal is to shift the reader's perspective of archaeology away from seeing it as a primarily data gathering field, to a clearer understanding of how archaeologists make and use the data they uncover.
Community Wealth Building and the Reconstruction of American Democracy
How can we create and sustain an America that never was, but should be? How can we build a robust multiracial democracy in which everyone is valued and everyone possesses political, economic and social capital? How can democracy become a meaningful way of life, for all citizens? By critically probing these questions, the editors of Community Wealth Building and the Reconstruction of American Democracy seize the opportunity to bridge the gap between our democratic aspirations and our current reality.
Invisible Labour in Modern Science
This book explores how and why some people and practices are made invisible in science, featuring 25 case studies and commentaries that explore how invisibility can bolster or undermine credibility, how race, gender, class, and nation frame who can see what, how invisibility empowers and marginalizes, and the epistemic ramifications of concealment.
Human Migration
Studies are shown on many aspects of migration, population development, human genetics, archaeology, anthropology, biology, linguistics, and a broad range of genomic studies on migration and cultural and social structures in the past and present. Human migration started in Africa spread to Asia and other regions of our globe and was assessed by studies on ancient and contemporary mtDNA sequencing distributed from the artic to South America. The evolutionary consequences of the settlement of the Aleutian Islands, Samoyedic-speaking populations from Siberia; early human migrations in Gabon Africa, the Republic of Sakha (formerly, Yakutia), African migration to Europe during the twenty-first ce...
The Oxford Handbook of Research Ethics
The development of new pharmaceutical products and behavioral interventions aimed at improving people's health, as well as research that assesses the efficacy and cost-effectiveness of public policies, such as policies designed to improve children's education or reduce poverty, depends on research conducted with human participants. It is imperative that research with human subjects is conducted in accordance with sound ethical principles and regulatory requirements. Featuring 45 original essays by leading research ethicists, The Oxford Handbook of Research Ethics offers a critical overview of the ethics of human subjects research within multiple disciplines and fields, including biomedicine, public health, psychiatry, sociology, political science, and public policy.
The Promise and Peril of CRISPR
"Comprising eight revised essays and seven new pieces, this work provides a comprehensive resource for students, scientists, bioethicists, physicians, and laypeople to better understand and discuss the ethical issues underlying this technology that has the potential to forever change the world"--
Double Helix History
Double Helix History examines the interface between genetics and history in order to investigate the plausibility of ‘new’ knowledge derived from scientific methods and to reflect upon what it might mean for the practice of history. Since the mapping of the human genome in 2001, there has been an expansion in the use of genetic information for historical investigation. Geneticists are confident that this has changed the way we know the past. This book considers the practicalities and implications of this seemingly new way of understanding the human past using genetics. It provides the first sustained engagement with these so-called ‘genomic histories’. The book investigates the ways ...
