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Nucleic Acid Switches and Sensors
This book reviews studies showing that interesting and useful molecular-scale switches and sensors can be made out of nucleic acids, by both artificial and natural means. The first section of the book is devoted to artificial nucleic acid switches and sensors. In second section, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist, in the evolution of natural nucleic acid switches and sensors.
The Aptamer Handbook
In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.
Ceramide Signaling
The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.
Rethinking the Relationship between International, EU and National Law
Provides new insights for solving conflicts between International, EU and National Law by rethinking the relationship between the three.
The Politics of Dependence
The central claim of this book is that the dichotomy between economic dependence and economic independence is completely inadequate for describing the political challenges faced by contemporary capitalist welfare states. The simplistic contrast between markets and states as sources of income renders invisible the relations of dependence established in our basic economic institutions such as the family, property, and money. This book is a work of political theory that attacks narrow conceptions of dependence and identifies distinct senses of dependence that might allow political communities to make clearer decisions about the justice of our economic institutions and practices. Inheritance, for example, is as much a form of dependence as support by a welfare state, but these are never compared in debates about economic justice. This book begins the work of comparing forms of economic dependence, and argues that economic dependence is always an issue of both vulnerability and parasitism. It builds bridges between political theory and social science, and is of relevance to those concerned with social and economic justice in and beyond contemporary capitalist welfare states.
Handbook of RNA Biochemistry
The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.
Survival and Witness at Europe's Border
Survival and Witness at Europe's Border focuses on one of the most mediatized migrant disasters in Europe. On October 3, 2013, an overcrowded fishing boat carrying Eritrean refugees caught fire near Lampedusa, Italy, where 368 people died. Karina Horsti shows with empathy and passion how this disaster produced a kaleidoscope of afterlives that continue to assume different forms depending on the position of the witness or survivors. Pasts and futures intersect in the present when people who were touched by the disaster engage with its memory and politics. Horsti underscores how the perspective of survival can envision a way forward from a horrific unsustainable present. Survival and Witness at Europe's Border develops the concept of survival to rethink border deaths beyond the structures and processes that produce the murderous border and constitute the focus of critical migration studies. It demonstrates how the process of survival transforms people and societies. Survival is productive, Horsti argues, shifting the focus in migration studies from apparatuses of control to emphasize the agency and subjectivity of refugees.
Who Needs God?
We are experiencing a dramatic social upheaval in today's world, a breakdown of our living conditions and values. Political boundaries become less important, social structures seem to disintegrate-all is subordinated to cash flow and profit maximization. With growing individualism, the concept of the good and proper life has been lost. This does not produce living conditions that facilitate belief in God, contact with God, as one perhaps had during childhood. The longing for old values such as faith and deeper spiritual meaning has consequently been reawakened.
Racism and Early Blackface Comic Traditions
This book traces blackface types from ancient masks of grinning Africans and phallus-bearing Roman fools through to comedic medieval devils, the pan-European black-masked Titivillus and Harlequin, and racial impersonation via stereotypical 'black speech' explored in the Renaissance by Lope de Vega and Shakespeare. Jim Crow and antebellum minstrelsy recycled Old World blackface stereotypes of irrationality, ignorance, pride, and immorality. Drawing upon biblical interpretations and philosophy, comic types from moral allegory originated supposedly modern racial stereotypes. Early blackface traditions thus spread damning race-belief that black people were less rational, hence less moral and less human. Such notions furthered the global Renaissance’s intertwined Atlantic slave and sugar trades and early nationalist movements. The latter featured overlapping definitions of race and nation, as well as of purity of blood, language, and religion in opposition to 'Strangers'. Ultimately, Old World beliefs still animate supposed 'biological racism' and so-called 'white nationalism' in the age of Trump.
