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Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Targeting Protein-Protein Interactions by Small Molecules
This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Homiletic Directory
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Medicinal Chemistry for Practitioners
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Tractates on the Gospel of John 1–10 (The Fathers of the Church, Volume 78)
No description available
The Hermeneutics of the Apostolic Proclamation
Bates applies his method to both oft-referenced and underutilized passages in the writings of Paul and suggests a new model for Pauline hermeneutics that is centered on the apostolic proclamation of Christ.--Michael J. Gorman, Dean, Ecumenical Institute of Theology "St. Mary's Seminary & University"
The Fiske Guide to Colleges 2015
"The best college guide you can buy."-USA Today This leading guide to more than 300 colleges and universities has been an indispensable source of information for college-bound students and their parents. Hip, honest, and straightforward, The Fiske Guide to Colleges delivers an insider's look at the academic climates and the social and extracurricular scenes at the "best and most interesting" schools in the U.S., Canada, Great Britain, and Ireland. Includes: * Fiske's exclusive academic, social, and quality-of-life ratings * Fiske's "Best Buys:" schools that deliver the best education at the most reasonable costs * Lists of each school's strongest majors and programs * Candid comments from each school's current students * A self-quiz to help students understandwhich college is right for them And more!
Painting Missouri
With more counties than most other states, Missouri posed a unique challenge for Billyo O'Donnell. Setting out to create an outdoor painting on location - en plein air - for each of Missouri's 114 counties plus the city of St. Louis, this award-winning artist devoted years of travel and logged more than 150,000 miles to capture the many textures of a multifaceted state.
Painting Missouri is an extraordinarily rich collection of scenes and seasons along the highways and byways of the Show-Me State. Turn these pages to find a farmer driving a combine in a Ray County cornfield or the Benedictine convent in Nodaway County or mist rising from snow at sunrise in Prairie State Park. Here a...
Revelation (Catholic Commentary on Sacred Scripture)
In this addition to the well-received Catholic Commentary on Sacred Scripture (CCSS), seasoned New Testament scholar and popular speaker Peter Williamson interprets Revelation from within the living tradition of the Church for pastoral ministers, lay readers, and students alike. The seventeen-volume CCSS series, which will cover the entire New Testament, relates Scripture to Christian life today, is faithfully Catholic, and is supplemented by features designed to help readers understand the Bible more deeply and use it more effectively in teaching, preaching, evangelization, and other forms of ministry. Drawn from the best of contemporary scholarship, series volumes are keyed to the liturgical year and include an index of pastoral subjects.
