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Proton Pump Inhibitors
Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.
House documents
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Vibration-rotational Spectroscopy and Molecular Dynamics
The book reviews the results of vibration-rotational spectroscopy of molecules obtained recently by combining modern computational methods of quantum chemistry with the new techniques of high-resolution rotational and vibration-rotational spectroscopy. It shows for example that the tunneling vibration-rotational spectroscopy of the van der Waals complexes provides a new look at intermolecular forces while the high precision and sensitivity of the submillimeter-wave and Fourier transform microwave spectroscopy make it possible to study complex rotational spectra of molecules in excited vibrational states. New results of high level ab initio quantum chemical computations of vibrational and rotational energy levels and dipole moment functions of unusual molecules will be discussed together with the recent discovery of clustering of energy levels in asymmetric tops. Group theoretical analysis of floppy molecules, especially the tunneling effects in nonrigid molecules, will also be discussed.
Historic Alabama Courthouses
Alabama’s oldest courthouses have witnessed a panorama of history. Historic Alabama Courthouses resurrects historical facts and images of buildings that were the centers of much of the state’s public life during its first century. Photographs of more than 120 buildings, the earliest that the author could find for each structure, are gathered in this significant volume along with historical, architectural, social, legal, and political accounts of their contributions to the landscape of Alabama. Historic Alabama Courthouses also emphasizes architects and builders. Although the names of many of the principals are unknown, those who can be identified play large roles in the stories told in the book. Not only are the architects’ personal histories important, but also the history of the architecture profession in the state can be observed through the relationships and projects they created. Finally, the stories of Alabama’s courthouse builders and contractors are accounts of technical innovation, entrepreneurship, and sometimes imitation, revealing that fashions spread as widely and rapidly in building design and construction as in any other endeavor.
