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The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans. Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Glycotechnology brings together in one place important contributions and up-to-date research results in this fast moving area. Glycotechnology serves as an excellent reference, providing insight into some of the most challenging research issues in the field.
Saccharides are widely distributed in all living life forms and glycobiology is the study of their structure, biosynthesis, biology, and evolution. It is a rapidly growing field, relevant to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and their analysis and manipulation. Essentials of Glycobiology is the field's most authoritative textbook, offering an overview suitable for advanced undergraduates and graduate students in molecular and cellular biology and biomedicine. In an entirely revised and updated fourth edition, the book retains a broad focus and applicability to fields ranging from biology and medicine to chemistry and materials science, with excellent artwork and chapters written by an international selection of leading investigators.
Galectins: Methods and Protocols is the first book solely dedicated to methodological approaches designed to study galectin function. The galectin family represents one of the most pleiotropic families, with individual members having been implicated in various aspects of nearly every biological process described, from RNA splicing to complex regulatory circuits that orchestrate adaptive immunity. Given the diverse roles of galectins in a variety of biological systems, studying these glycan binding proteins often requires the assimilation of diverse technical skills to fully appreciate their biological function. Their nearly ubiquitous expression and ability to bind highly modifiable carbohyd...
One hundred and fifty-six poems, grouped by theme, are accompanied by drawings, oils, and watercolors by the poet.
Galectins: Methods and Protocols is the first book solely dedicated to methodological approaches designed to study galectin function. The galectin family represents one of the most pleiotropic families, with individual members having been implicated in various aspects of nearly every biological process described, from RNA splicing to complex regulatory circuits that orchestrate adaptive immunity. Given the diverse roles of galectins in a variety of biological systems, studying these glycan binding proteins often requires the assimilation of diverse technical skills to fully appreciate their biological function. Their nearly ubiquitous expression and ability to bind highly modifiable carbohyd...
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During the Cold War, Radio Free Europe and Radio Liberty broadcast uncensored news and commentary to people living in communist nations. As critical elements of the CIA's early covert activities against communist regimes in Eastern Europe, the Munich-based stations drew a large audience despite efforts to jam the broadcasts and ban citizens from listening to them. This history of the stations in the Cold War era reveals the perils their staff faced from the Soviet Union, Bulgaria, Romania and other communist states. It recounts in detail the murder of writer Georgi Markov, the 1981 bombing of the stations by "Carlos the Jackal," infiltration by KGB agent Oleg Tumanov and other events. Appendices include security reports, letters between Carlos the Jackal and German terrorist Johannes Weinrich and other documents, many of which have never been published.