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Living in Medieval England
1326 was one of the most dramatic years in English history. The queen of England, Isabella of France, invaded the country with an army of mercenaries to destroy her husband's powerful and detested lover, Hugh Despenser the Younger, and brought down her husband King Edward II in the process. It was also a year, however, when the majority of English people carried on living their normal, ordinary lives: Eleyne Glaswreghte ran her own successful glass-making business in London, Jack Cressing the master carpenter repaired the beams in a tower of Kenilworth Castle, Alis Coleman sold her best ale at a penny and a half for a gallon in Byfleet, and Will Muleward made the king 'laugh greatly' when he...
Biomarkers of Neuroinflammation
Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum...
Endothelial Signaling in Development and Disease
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristic...
Nanoarchitectonics for Brain Drug Delivery
This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoreti...
The Tudors on Film and Television
With its mix of family drama, sex and violence, Britain's Tudor dynasty (1485-1603) has long excited the interest of filmmakers and moviegoers. Since the birth of movie-making technology, the lives and times of kings Henry VII, Henry VIII, and Edward VI and queens Mary I, Jane Grey and Elizabeth I have remained popular cinematic themes. From 1895's The Execution of Mary Stuart to 2011's Anonymous, this comprehensive filmography chronicles every known movie about the Tudor era, including feature films; made-for-television films, mini-series, and series; documentaries; animated films; and shorts. From royal biographies to period pieces to modern movies with flashbacks or time travel, this work reveals how these films both convey the attitudes of Tudor times and reflect the era in which they were made.
Desperate Prayers
Do your prayers resemble last-minute cries more than first-response chats? You’re not alone in calling out to God in life’s pitch-black moments and wondering if He’s listening. Enter the powerful secrets of the Bible's eleventh-hour pleas of fifteen men and women. This engaging book invites you into the prayer stories of struggling Bible characters like Hagar, Hannah, and David. Each chapter's simple three-word prayer focus will deepen your trust and affirm your heart that it’s best to be you before God. The ideal desperate pray-er to shine light on your prayer dilemmas, Rachel Wojo vulnerably shares her heartbreaking experiences of loss while pointing you to your Father. Her prayer journey and promising principles will guide you from frenzied desperation to dependent faith. When you finish Desperate Prayers: Embracing the Power of Prayer in Life's Darkest Moments, you’ll know that praying in a panic creates a powerful pathway to peace.
Ontogeny and Phylogeny of Brain Barrier Mechanisms
The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in develo...
Overcoming Chronic Digestive Conditions
A holistic approach for healing trauma stored in the gut • Explains how and why emotions and trauma are stored in the gut, causing digestive issues and visceral tensions • Presents recent research that enriches our understanding of the gut as a center of emotional and spiritual growth • Shares a hands-on process of listening to the gut layer by layer to help heal gut issues, renew the microbiome, and release intergenerational trauma A healthy gut is fundamental to a healthy life. Embedded within our digestive system is the enteric nervous system, our “second brain,” which serves to protect us from the external world of adversity, including not only viruses and bacteria, but also ...
The Autobiography of a Transgender Scientist
A POIGNANT LGBT MEMOIR: A leading trans neuroscientist recounts his gender transition, his groundbreaking scientific work, and his advocacy for gender equality in STEM. “A portrait of a singular personality that was shaped by his status as an outsider.” —Science Ben Barres was known for his groundbreaking scientific work and advocacy for gender equality in science. In this autobiography, completed shortly before his death from pancreatic cancer in December 2017, Barres (born in 1954) describes a life full of remarkable accomplishments—from his childhood as a precocious math and science whiz to his experiences as a female student at MIT in the 1970s to his gender confusion and later t...
The Routledge Guide to William Shakespeare
Demystifying and contextualising Shakespeare for the twenty-first century, this book offers both an introduction to the subject for beginners as well as an invaluable resource for more experienced Shakespeareans. In this friendly, structured guide, Robert Shaughnessy: introduces Shakespeare’s life and works in context, providing crucial historical background looks at each of Shakespeare’s plays in turn, considering issues of historical context, contemporary criticism and performance history provides detailed discussion of twentieth-century Shakespearean criticism, exploring the theories, debates and discoveries that shape our understanding of Shakespeare today looks at contemporary performances of Shakespeare on stage and screen provides further critical reading by play outlines detailed chronologies of Shakespeare’s life and works and also of twentieth-century criticism The companion website at www.routledge.com/textbooks/shaughnessy contains student-focused materials and resources, including an interactive timeline and annotated weblinks.
