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Chronic Myeloid Neoplasias and Clonal Overlap Syndromes
Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but si...
Material Matters
Our planet is a closed system with limited material resources, yet our current economic model is designed in a one-way direction from resource extraction to disposal, leading to resource depletion. This book proposes a new economic model, offering an alternative to this linear ‘take-make-waste’ economy. Material Matters shows a way of creating a circular economy by using the unlimited resources we have: renewable energy, data and intelligence. It describes a system based on circular business models centred on selling performance rather than ownership, designing products and buildings as resource banks and equipping products with a ‘material passport’ to ensure their usability for fut...
Coronavirus vol 3
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Hedgehog Signaling
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. Contributions from leading authorities Informs and updates on all the latest developments in the field
Colorectal Cancer Awareness Month 2023: Diagnosis, Clinical Course, and Surgical Management of Metastatic Colorectal Cancer
March is Colorectal Cancer Awareness Month and at Frontiers in Oncology we want to highlight the recent discoveries in the field and raise awareness of the importance of early diagnosis, multidisciplinary management, and technological innovation support. Colorectal cancer (CRC) is the third most common cancer worldwide and represents one of the most relevant challenges for present and future global health, with 50 % of patients affected by CRC developing metastasis. Despite the introduction of novel therapeutic approaches and anticancer drugs, colorectal metastatic cancer (mCRC) continue to have a poor prognosis. In the last years, the extensive investigation on biomarkers that could identif...
Interaction between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer
The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat wi...
ESMO Handbook on Principles of Translational Research
Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicativ
The Bob Dylan Encyclopedia
Music critic Michael Gray presents opinionated entries on hundreds of figures, musical works, and other widely varied topics related to singer-songwriter Bob Dylan. Also includes the text on CD-ROM.
Mystery Train
Now Available as an eBook Catch a train to the heart of rock ‘n’ roll with this essential study of the quintessential American art form. First published in 1975, Greil Marcus’ Mystery Train remains a benchmark study of rock ‘n’ roll and a classic in the field of music criticism. Focusing on six key artists--Robert Johnson, Harmonica Frank, Randy Newman, the Band, Sly Stone, and Elvis Presley--Marcus explores the evolution and impact of rock ‘n’ roll and its unique place in American culture. This sixth edition of Mystery Train includes an updated and rewritten Notes and Discographies section, exploring the evolution and continuing impact of the recordings featured in the book.
