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This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.
The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell wa...
This book explores the topic of peace and the long-term survival of the human species. Drawing on Existential Risk Studies (ERS), the book lays out a theoretical framework for drawing new perspectives and approaches for looking toward the future and addressing existential risks related to the complexity and dynamics of conflict. Looking at five research lines in Peace and Conflict Studies (PCS); (1) Great Powers Conflict, (2) Peace, Pandemic, and Conflict, (3) Climate, Peace, and Conflict, (4) Emerging Technologies, Peace, and Conflict and (5) Totalitarianism, the chapters discuss how these lines are defined and discussed, how they are understood in ERS, and what approaches would be beneficial to adapt and integrate into PCS. By drawing on ERS and grounding the discussion in lines of research that will be important to the field of PCS, this book suggests that long-term perspectives are needed in the field, especially in regard to existential risk and their implications of conflict.
A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotech and industrial uses. Special emphasis is given to the solving critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing compounds. Other topics include recombinant protein expression, bioinformatics, high throughput screening, analytical tools in biotechnology, DNA shuffling, and genomics discovery.
This book provides a comprehensive examination of biochemical and genetic regulatory phenomena as they relate to the activity of actinomycete secondary metabolic pathways and the functioning of secondary metabolites as endogenous effectors of cytodifferentiation. Approximately 50 illustrations accompany the text.
The normal course of most biologically catalyzed processes is tightly regulated at the genetic and physiological levels. The regulatory mechanisms are diverse, sometimes redundant, and it is becoming increasingly apparent that, at the genetic level, the range of mechanisms may be limited only by the permutations and combina tions available. For each microbial cell, evolution appears to have resulted in maximized advantage to that cell, achieving regulatory balance. Genetic engineering encompasses our attempts to perturb the genetic regulation of a cell so that we may obtain desired other than normal outcomes, such as increased product formation, or new product formation. Following the ground...
A celebrated biologist's manifesto addressing a soil loss crisis accelerated by poor conservation practices and climate change "Jo Handelsman is a national treasure, and her clarion call warning of a looming soil-loss catastrophe must be heard. Add her clearly written alarm to other future-shocks: climate change, pandemics, and mass extinctions."--Laurie Garrett, Pulitzer Prize winner and author of The Coming Plague: Newly Emerging Diseases in a World out of Balance "The ground beneath our feet is slipping away as we lose the precious soil that sustains us. Jo Handelsman's writing--as rich and life supporting as the soil itself--is a riveting warning."--Alan Alda, actor, writer, and host of ...