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Ecology and Evolution of Cancer
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ...
Adaptive Oncogenesis
Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over pre...
Exploratory Data Analysis Using Fisher Information
This book uses a mathematical approach to deriving the laws of science and technology, based upon the concept of Fisher information. The approach that follows from these ideas is called the principle of Extreme Physical Information (EPI). The authors show how to use EPI to determine the theoretical input/output laws of unknown systems. Will benefit readers whose math skill is at the level of an undergraduate science or engineering degree.
Genesis - In The Beginning
Genesis – In The Beginning deals with the origin and diversity of Life and early biological evolution and discusses the question of where (hot or cold sources) and when the beginning of Life took place. Among the sections are chapters dealing with prebiotic chemical processes and considering self-replication of polymers in mineral habitats. One chapter is dedicated to the photobiological regime on early Earth and the emergence of Life. This volume covers the role of symmetry, information and order (homochrial biomolecules) in the beginning of Life. The models of protocells and the genetic code with gene transfer are important topics in this volume. Three chapters discuss the Panspermia hypothesis (to answer “Are we from outer Space?”). Other chapters cover the Astrobiological aspects of Life in the Universe in extraterrestrial Planets of the Solar System and deal with cometary hydrosphere (and its connection to Earth). We conclude with the history and frontiers of Astrobiogy.
Cancer Bioinformatics
"The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book." —Dieter Naf, Jackson Laboratory, USA Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences. This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.
The Truth in Small Doses
A decade ago Leaf, a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress-- brilliant young scientists-- are now abandoning the search for a cure.
Science from Fisher Information
A new edition of the hugely successful 'Physics from Fisher Information'.
The Invisible Rainbow
The most misunderstood force driving health and disease The story of the invention and use of electricity has often been told before, but never from an environmental point of view. The assumption of safety, and the conviction that electricity has nothing to do with life, are by now so entrenched in the human psyche that new research, and testimony by those who are being injured, are not enough to change the course that society has set. Two increasingly isolated worlds--that inhabited by the majority, who embrace new electrical technology without question, and that inhabited by a growing minority, who are fighting for survival in an electrically polluted environment--no longer even speak the same language. In The Invisible Rainbow, Arthur Firstenberg bridges the two worlds. In a story that is rigorously scientific yet easy to read, he provides a surprising answer to the question, "How can electricity be suddenly harmful today when it was safe for centuries?"
