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Organotypic Models in Drug Development
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials
This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials. With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.
Environment and Skin
This book is a rich source of information on skin disorders due to toxicants in the environment. State of the art knowledge is summarized concerning the molecular basis of skin damage caused by well-appreciated environmental noxae. The book also provides a uniquely comprehensive overview of the detrimental dermatological effects of exposure to air pollution and global climate change. A special focus is contact allergy, which, beyond representing a major problem in dermatotoxicology, serves as a prime example for the development of toxicological approaches to risk assessment. A further chapter is devoted to contact urticaria, a condition that can progress to life-threatening anaphylactic reactions. The novel information offered in this book will enable the reader to go beyond the traditional thinking of dermatotoxicology and achieve a modern appreciation of the highly complex interplay between skin and environment.
Safety of Nanomaterials along Their Lifecycle
The incorporation of nanomaterials into products can improve performance, efficiency, and durability in various fields ranging from construction, energy management, catalysis, microelectronics, plastics, coatings, and paints to consumer articles such as foods and cosmetics. But innovation never comes at zero risk. The potential hazards resulting from human exposure during production, use, or disposal has raised concerns and targeted research early on. Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards presents the state of the art in nanosafety research from a lifecycle perspective. Although major knowledge gaps still exist, solid data are now available to id...
Nanomaterials
Production of nanomaterials has been constantly evolving over the last few years for manifold applications in electronic, optical and biomedical fields. As a result, exposure towards nanoparticles in the workplace environment is increasing, while respective occupational exposure limits are lacking. The Deutsche Forschungsgemeinschaft's Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) recognized the importance of a scientifically based approach to the risk assessment of nanoparticles at the workplace and in 2009 established the ad-hoc working group ?Nanoparticles'. Its task was to review the current database available for risk assessment for nanoparticles, to identify relevant endpoints of toxicological concern and to define open questions for future research. This report contains overviews on the important toxicological aspects of the nanoparticles and a summary and conclusions of the discussions that took place during the meetings of the ad hoc working group ?Nanoparticles'.
Nanomanufacturing Techniques in Sustainable Healthcare Applications
The text begins by discussing the processing and characterization of nano-manufactured resorbable bionanocomposites and presents the latest advances in carbon-based polymer nanocomposite materials for sensing applications. It further presents different characterization techniques such as scanning electron, transmission electron, atomic force microscopy, and powder X-ray diffraction for the identification of bionanocomposites. This book: • Introduces nano-manufactured processed composites for biomedical application, processing, and characterization of bionanocomposites. • Presents biobased nano-manufactured processed composites for imaging, tissue repairing, and drug-delivery applications...
Alternatives for Dermal Toxicity Testing
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
Benjamin Franklin Book of Recipes
This is a collection of recipes from the time of Benjamin Franklin, complemented by anecdotes about his extraordinary life in Boston and Philadelphia, London and Paris. Each chapter is set at a location where Franklin lived or was a visitor, and the menus reflect the food eaten at that time. The recipes are from several sources, including some by the great statesman himself. Among the period recipes and anecdotes, the reader will encounter some more modern recipes, and excursions into the origins of food and drink, all served with a liberal scattering of Franklin's quotations.
The MAC Flyer
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