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Methionine Dependence of Cancer and Aging
This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Methionine Dependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."
Patient-Derived Mouse Models of Cancer
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
Accelerated Expertise
Speed in acquiring the knowledge and skills to perform tasks is crucial. Yet, it still ordinarily takes many years to achieve high proficiency in countless jobs and professions, in government, business, industry, and throughout the private sector. There would be great advantages if regimens of training could be established that could accelerate the achievement of high levels of proficiency. This book discusses the construct of ‘accelerated learning.’ It includes a review of the research literature on learning acquisition and retention, focus on establishing what works, and why. This includes several demonstrations of accelerated learning, with specific ideas, plans and roadmaps for doing...
Blind Spot
Doug Kaplan seemed to be doing about as well as one could hope. He had a beautiful and loving wife, three healthy boys, and a successful career. He also had a neighbor who seemed to exist for the very purpose of driving him crazy. Trudy Fleischmann was a force of nature, a presence to be reckoned with for sure. She didn't mean any harm, but if she had a thought, or an opinion, she was going to share it with whomever happened to be in her crosshairs, and lately that had been Doug. The problem was, nobody else seemed to mind Trudy, and this made Doug even crazier. With peaceful coexistence seemingly beginning to fail, it appeared as if an ugly conflict between Doug and his elderly German immigrant neighbor was going to be unavoidable, until the accident, the accident that changed everything. Now, in the aftermath of a moment of carelessness, everything Doug holds near and dear is at risk of being taken from him, and now the one individual whom he wished to see purged most of all from his life may hold the key to any chance of normalcy and happiness going forward in his life.
Fit for Duty
When facing threats of violence and terrorism, law enforcement officers are often critical first responders. The ability of these officers to be alert, physically ready, and mentally prepared to handle the hazardous situations that are a regular part of the profession is essential to their agencies and the communities they protect. Fit for Duty, Third Edition With Online Video, provides practical information on creating and implementing physical fitness and wellness programs to help law enforcement officers fulfill their demanding job requirements. Authors Robert Hoffman and Thomas R. Collingwood offer a comprehensive resource with job-specific training and strategies supported by more than ...
Applied Concept Mapping
The expanding application of Concept Mapping includes its role in knowledge elicitation, institutional memory preservation, and ideation. With the advent of the CmapTools knowledge modeling software kit, Concept Mapping is being applied with increased frequency and success to address a variety of problems in the workplace.Supported by business appl
Meeting Excellence
Meeting Excellence is a comprehensive resource that provides a wide range of ready-to-use tools that have been developed and tested by a meeting initiative within Novartis Pharmaceuticals. It is based on years of research observing team meetings, examining existing meeting documents, and conducting a number of intensive individual interviews in the U.S. and Europe. This important book offers the information and tools needed to prepare, facilitate, and follow up on all your meetings. Step by step, Meeting Excellence shows how to Create an action-focused meeting agenda Ensure that everyone participates in discussion Deal with disruptive and inattentive people Develop a climate of trust among meeting participants Create and deliver effective meeting presentations Stay on track to achieve your meeting goals Achieve clear communication during a multicultural meeting Liven up a dreary and unproductive meeting Close your meeting on an upbeat and positive note Get action on team action items Improve meeting communications with line management Evaluate your meeting quickly and effectively Choose among various web-based meeting tools
