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Cardiovascular Specific Gene Expression
Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects ...
Data in Medicine: Collection, Processing and Presentation
Nowadays clinical medicine is to a great extent dependent on techniques and instrumentation. Not infrequently, instrumentation is so complicated that technical specialists are required to perform the measurements and to process the data. Interpretation of the results, however, generally has to be done by physicians. For proper interpretation of data and good com munication with technical specialists, knowledge of, among other things, principle, advantages, limitations and applicability of the used techniques is necessary. Besides, this knowledge is required for critical comparison of systems to measure a certain variable. Critical evaluation as well as com parison of techniques and instrumen...
Cardiac Electrophysiology, Circulation, and Transport
The cardiac system represents one of the most exciting challenges to human ingenuity. Critical to our survival, it consists of a tantalizing array of interacting phenomena, from ionic microscopic transport, membrane channels and receptors through cellular metabolism, energy production to fiber mechanics, microcirculation, electrical activation to the global, clinically observed, function, which is measured by pressure, volume, coronary flow, heart rate, shape changes and responds to imposed loads and pharmaceutical challenges. It is a complex interdisciplinary system requiring the joint efforts of the life sciences, the exact sciences, engineering and technology to understand and control the...
Oxygen Transport to Tissue XXV
The 30th scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) was held at the Western Conference Centre, UMIST, Manchester, in August 2002. It was attended by some 96 delegates and accompanying persons and there were 128 presentations.
Systolic and Diastolic Function of the Heart
Chapter 22: Crossbridge and Muscle Properties, Energetics, and Pressure-Volume Area -- Chapter 23: Constancy and Variability of Oxygen Costs of Mechanical Energy (PVA) and Contractility (Emax) -- Chapter 24: Tight Coupling between Regional Myocardial Oxygen Consumption and Contractile Function -- Chapter 25: Force-Frequency Relation, Force-Interval Relation, and Mechanical Restitution -- Chapter 26: Elastance-Based Mechanical Restitution Provides Data from the Intact Heart Not Available from Any Other Technique -- Chapter 27: Contractility Indices -- Chapter 28: Searching for Indices of Contractility Is Counterproductive -- Chapter 29: Rapid Contractile Upregulation Rematches Stroke Work to ...
Analysis and Simulation of the Cardiac System Ischemia
Over thiry-five experts contribute to this publication about the various interactions and interrelationships of the parameters which affect the normal and ischemic heart. Mechanical aspects related to the global and regional function of the heart are discussed. Coronary perfusion of the ischemic heart is considered, with emphasis on the effects of reperfusion. Electrical activation, formation of arrhythmias, and the effects of ischemia or ionic transport in the myocardium are presented. Metabolic aspects of the ischemic heart, including calcium transport, are also explained.
Cerebrovascular Ultrasound
Ultrasound provides a unique diagnostic perspective in cerebrovascular disorders, with extremely high temporal resolution and excellent spatial display of extracranial arteries, brain structures and cerebral vessels. This comprehensive text covers the fundamentals of ultrasound physics, new technology, and clinical applications in all ages. It provides a firm grounding in hemodynamics and describes computational models for study of the cerebral circulation. Extracranial applications in assessing the carotid and vertebral arteries are discussed in detail, as are intracranial Doppler applications in stroke, subarachnoid hemorrhage, arteriovenous malformations, interventional and surgical procedures, and the detection and monitoring of cerebral microembolism. These and other topics, both clinical and technical, are presented by leading authorities in the field, with extensive illustrations, and tables are included for the standardized classification of cerebrovascular diseases based on international consensus conferences. For clinicians and clinical neuroscientists this is the definitive reference text in cerebrovascular ultrasound.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Cell Chemistry and Physiology: Part I
This is the first of a 4-volume module that is an introduction to the study of cell chemistry and physiology. It is not intended to be encyclopedic in nature but rather a general survey of the subject with an emphasis on those topics that are central to an understanding of cell biology and those that are certain to become of increasing importance in the teaching of modern medicine.We have followed what appeared to as to be the logical divisions of the subject beginning with proteins. Allewell and her colleagues stress the point that proteins fold spontaneously to form complex three-dimensional structures and that some of them unfold with the help of proteins called chaperones. Michaelis-Ment...
