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Neuronal mechanisms of epileptogenesis
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain ar...
Neurodegeneration: From Genetics to Molecules
Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's diseas...
Sleep and Chronobiology in Plasticity and Memory
Chronobiological mechanisms regulating time-of-day mediated behaviors, such as sleep and circadian rhythms, are thought to interact with and/or share cellular and molecular signaling cascades that shape synaptic plasticity and neural excitability. These same factors are also known to underlie events that govern higher-order cognitive processing, including learning and memory formation, and often through phylogenetically conserved pathways. This suggests that factors which contribute to adaptive responses to changing environmental stimuli are likely derived from basic evolutionarily ancient processes, and underscores the importance of using both invertebrate and vertebrate models to study the interaction of chronobiology and cognitive processing. This issue highlights current views along with original research on sleep and circadian features of plasticity and memory in multiple species, models, and systems.
Landslide Science and Practice
This book contains peer-reviewed papers from the Second World Landslide Forum, organised by the International Consortium on Landslides (ICL), that took place in September 2011. The entire material from the conference has been split into seven volumes, this one is the second: 1. Landslide Inventory and Susceptibility and Hazard Zoning, 2. Early Warning, Instrumentation and Monitoring, 3. Spatial Analysis and Modelling, 4. Global Environmental Change, 5. Complex Environment, 6. Risk Assessment, Management and Mitigation, 7. Social and Economic Impact and Policies.
SOCCER WORLD 2011/12
SOCCER WORLD 2011/12 contiene i profili di circa 400 formazioni con anagrafica di oltre 16.000 calciatori distribuiti in 30 campionati tra europei, nord-sudamericani ed asiatici aggiornati alla stagione 2011/12. I dati societari di tutti i club presenti, gli organici delle squadre minuziosamente aggiornati, le disposizioni in campo dei giocatori e tutti i principali movimenti di calciomercato, sono il punto di forza della pubblicazione. La completa analisi statistica della stagione internazionale 2010/11 grazie ai tabellini con i marcatori di tutte le partite giocate unita alle classifiche di Prima e Seconda Divisione di ogni campionato, promozioni e retrocessioni, le coppe nazionali, le presenze e le reti di tutti i giocatori e le statistiche delle ultime 10 stagioni per ogni campionato e le coppe internazionali rendono il tutto qualcosa di completo ed unico nel suo genere. Il tutto contribuisce a rendere questo volume forse il più originale per quanto concerne le squadre di calcio.
Dependable Computing - EDCC 2005
It is always a special honor to chair the European Dependable Computing C- ference (EDCC). EDCC has become one of the well-established conferences in the ?eld of dependability in the European research area. Budapest was selected as the host of this conference due to its traditions in organizing international scienti?c events and its traditional role of serving as a meeting point between East and West. EDCC-5 was the ?fth in the series of these high-quality scienti?c conf- ences. In addition to the overall signi?cance of such a pan-European event, this year’s conference was a special one due to historic reasons. The roots of EDCC date back to the moment when the Iron Curtain fell. Originall...
Collective Leadership and Divided Power in West European Parties
Political science research, especially in recent times, has recognized the centrality of party and executive leaders and their individual characteristics. The attention has been mostly directed towards individual leadership. However, one-chief leadership is not the only existing model of party governance, and some recent developments seem to have put forms of collective leadership into the spotlight. Two parties that have recently achieved remarkable electoral results, the Italian Five Star Movement and the German Alliance 90/The Greens, can be considered examples of alternative models of leadership. This book calls for a deep and systematic analysis of cases of parties in which powers and r...
