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A Role for the Let-7 Primary MicroRNA in Target Gene Recognition and Repression
MicroRNA (miRNA) genes produce three noncoding RNA products: the long primary transcript (pri-miRNA), the ~70 nucleotide pre-miRNA, and the ~22-nt mature miRNA. Only the mature miRNA is considered to be the functional species of a miRNA gene in recognizing cognate target mRNAs and modulating their expression. However, mature miRNAs are processed from the primary transcript through sequential endonucleolytic steps. As a result, the mature miRNA sequence is present in all three RNA products of a miRNA gene. It has thus been intrinsically difficult to determine the contribution of each miRNA gene product to target repression. In fact, direct functional roles for pri- and pre-miRNAs have never b...
Adora and the Distance
A new YA fantasy graphic novel following the epic adventures of Adora, a brave young woman of color who lives in a fantastical world with underground pirates, ghosts, and a mysterious force called “The Distance.” The Distance threatens to destroy it all, and only Adora can stop it! From Marc Bernardin—the award-winning television writer/producer on Star Trek: Picard, Critical Role: The Legend of Vox Machina, Masters of the Universe: Revelations, Castle Rock, and Mata Hari’s Ariela Kristantina. Includes an introduction by Damon Lindelof (Lost, The Leftovers, HBO's The Watchmen)! "Marc Bernardin's gorgeous, powerful Adora and the Distance was his way of connecting with a child on the A...
B.P.R.D. Hell on Earth Volume 4
The B.P.R.D takes on the apocalypse! The B.P.R.D. continues to lead the defense against the apocalyptic Ogdru Hem from Japan to America, as the team splits up and Kate is possessed. Howards and a team of agents find themselves attempting to liberate a small town that holds secrets from Howards' Hyperborean past. Elsewhere, B.P.R.D. field agent Ashley Strode attempts to purge a demon from a 100-year-old exorcist, setting her on a path to battling a demon who is kidnapping and eating children. A new format for this collection of spine-tingling horror from Mignola and others, this edition collects B.P.R.D. Hell on Earth volumes 10-11 and 14, for the first time in paperback, plus bonus material!
Avatar: The Last Airbender--The Search Omnibus
Immediately following the Avatar's adventures chronicled in The Promise, this remarkable omnibus that collects parts 1-3 of The Search, from Airbender creators Michael Dante DiMartino and Bryan Konietzko! For years, fans of Avatar: The Last Airbender and The Legend of Korra have burned with one question--what happened to Fire Lord Zuko's mother? Finding a clue at last, Zuko enlists the aid of Team Avatar--and the most unlikely ally of all--to help uncover the biggest secret of his life.
Science and Life
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Poetry in Pieces
Set against the cultural and political backdrop of interwar Europe and the Americas, Poetry in Pieces is the first major study of the Peruvian poet César Vallejo (1892–1938) to appear in English in more than thirty years. Vallejo lived and wrote in two distinct settings—Peru and Paris—which were continually crisscrossed by new developments in aesthetics, politics, and practices of everyday life; his poetry and prose therefore need to be read in connection with modernity in all its forms and spaces. Michelle Clayton combines close readings of Vallejo’s writings with cultural, historical, and theoretical analysis, connecting Vallejo—and Latin American poetry—to the broader panorama of international modernism and the avant-garde, and to writers and artists such as Rainer Maria Rilke, James Joyce, Georges Bataille, and Charlie Chaplin. Poetry in Pieces sheds new light on one of the key figures in twentieth-century Latin American literature, while exploring ways of rethinking the parameters of international lyric modernity.
We Have Demons
From comic-book superstars SCOTT SNYDER and GREG CAPULLO (Batman, Batman: Last Knight on Earth, Dark Nights: Metal & Death Metal) comes a new blockbuster series of biblical proportions. Since the very dawn of man, legends have been told of the conflict between angel and demon-kind. Lam Lyle, a woman of science, dismissed these stories as just that — fiction. But when the loss of a loved one leads to the discovery of a hulking, benevolent demon named Gus, Lam realizes that her life is about to undergo a dire new direction. With a newfound partner and awesome powers now at her disposal, our hero suddenly finds herself thrust into a climactic war of good and evil with no less than the fate of the world hanging in the balance… Includes sketch material and original scripts.
Forgotten Home
While investigating a series of child abductions in Montana, the case gets personal for Sheriff's Deputy Lorraine Adalet when her teenage daughter, Joanna, disappears with a friend. Following the clues of otherworldly evidence leads Lorraine back to her long abandoned homeworld of Jannada. Mired in a never-ending war she escaped long ago, Lorraine had hoped to protect Joanna from her own past. Once in Jannada, she attempts a rescue mission to bring Joanna and the rest of the kidnapped children back to Earth; however, it's not without resistance. Lorraine must confront her past with the evil Jannadan Queen and everyone else she abandoned all those years ago…not to mention an entire army of magic-wielding children! Meanwhile, Joanna's allegiance hangs in the balance in this tale of family and fate. Collects Forgotten Home from the ComiXology original digital series, in print for the first time!
Cultural Encounters
More than just an expression of religious authority or an instrument of social control, the Inquisition was an arena where cultures met and clashed on both shores of the Atlantic. This pioneering volume examines how cultural identities were maintained despite oppression. Persecuted groups were able to survive the Inquisition by means of diverse strategies—whether Christianized Jews in Spain preserving their experiences in literature, or native American folk healers practicing medical care. These investigations of social resistance and cultural persistence will reinforce the cultural significance of the Inquisition. Contributors: Jaime Contreras, Anne J. Cruz, Jesús M. De Bujanda, Richard ...
