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The Extraordinary Biology of the Naked Mole-Rat
This volume focuses on the huge advances in the last 25 years on the use of this animal model for biomedical research (cancer, heart disease and neurodegeneration), fundamental neuroscience and basic subterranean biology. In 2013, Science magazine named the naked mole-rat as the Vertebrate of the Year. This was partly due to research carried out documenting its extreme longevity, negligible senescence, and prolonged maintenance of cancer free, good health well into old age as well as seminal work on mechanisms involved in these processes, pain and hypoxia resistance. In addition to this research focus on longevity and chronic diseases such as cancer and cardiovascular disease, the naked mole-rat has also made a substantial contribution to the fields of ecophysiology, neuroscience and behavior. With international contributions, this book provides a valuable text for zoological students, behavioral scientists and biomedical researchers.
Life Underground
Many mammals like to dig in the dirt, but few call it home. Those that do, such as mole-rats, zokors, and tuco-tucos, have developed novel adaptations to their subterranean life, including bones and muscles modified for efficient digging and ways to "see" underground without using their eyes. These unusual traits, adopted independently by unrelated groups around the world, also make subterranean rodents fascinating subjects for biologists. Life Underground provides the first comprehensive review of the biology of subterranean rodents. Arranged by topic rather than by taxon to facilitate cross-species comparisons, chapters cover such subjects as morphology, physiology, social behavior, genetic variation, and evolutionary diversification. Two main questions run throughout the book. First, to what extent has subterranean life shaped the biology of these animals, leading to similar adaptations among otherwise dissimilar species? Second, how have the distinct evolutionary histories of these groups led to different solutions to the challenges posed by life underground?
The Longevity Seekers
“[A] beautifully told story of twenty-first-century researchers in pursuit of the secrets of longevity . . . a book both engaging and illuminating.” —Deborah Blum, Pulitzer Prize-winning author People have searched for the fountain of youth everywhere from Bimini to St. Augustine. But for a steadfast group of scientists, the secret to a long life lies elsewhere: in the lowly lab worm. By suppressing the function of just a few key genes, these scientists were able to lengthen worms’ lifespans up to tenfold, while also controlling the onset of many of the physical problems that beset old age. As the global population ages, the potential impact of this discovery on society is vast—as ...
Wildlife Review
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Peroxiporins
To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emit...
Body Recomposition
Obesity is a global pandemic rising beyond the status of a lifestyle disorder, and its consequences include impaired metabolism, energy disruption, and abdominal fat deposition and storage. Body Recomposition: A Comprehensive and Metabolic Alternative to Weight Loss presents information on body recomposition, which emphasizes the approach of losing fat while gaining muscle. It contains vast research on topics including factors that influence fat accumulation, strategies for weight management, healthy diet and eating patterns, physical exercise, and lifestyle strategies in healthy weight management. Features: Influence of non-alcoholic fatty liver disease (NAFLD) on stored fat accumulation an...
Sourcebook of Models for Biomedical Research
The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.
Comparative Biology of Aging
determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) v...
Porcupines
Porcupines are prickly and often misunderstood creatures—get the facts. Could a porcupine make a good pet? Do they ever stick themselves or other porcupines with their quills? In this latest addition to the Animal Answer Guide series, we learn about these mysterious animals' "pincushion defense," along with the following facts: • Porcupines survive on a diet of leaves, bark, and fruit • Quills are actually modified hairs • There are 26 species of porcupines (and counting) • Old World and New World porcupines have a common ancestor but evolved independently • New World males will gather to fight ferociously over a single female Porcupines: The Animal Answer Guide presents solid, c...
The Future of Immortality
A gripping account of the Russian visionaries who are pursuing human immortality As long as we have known death, we have dreamed of life without end. In The Future of Immortality, Anya Bernstein explores the contemporary Russian communities of visionaries and utopians who are pressing at the very limits of the human. The Future of Immortality profiles a diverse cast of characters, from the owners of a small cryonics outfit to scientists inaugurating the field of biogerontology, from grassroots neurotech enthusiasts to believers in the Cosmist ideas of the Russian Orthodox thinker Nikolai Fedorov. Bernstein puts their debates and polemics in the context of a long history of immortalist though...
