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A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
Glutathione in Health and Disease
Reduced glutathione (GSH) is the most important thiol in living organisms. It is the key component of antioxidant system and serves as a free radical scavenger. There is a cycle of GSH in biological systems and this cycle provides higher intracellular levels of GSH. GSH depletion and apparent oxidative stress may cause toxicity and can affect the general well-being of the organism. GSH was shown to be preventive against aging, cancer, heart disease, infections and dementia. This book is mainly focused on GSH in health and disease. The readers will gain qualified scientific knowledge on the diverse functions of GSH, the importance of GSH status against oxidative stress and the interaction between GSH and nervous system-related infections from this book.
A Research Agenda for Environmental Management
The understanding of global environmental management problems is best achieved through transdisciplinary research lenses that combine scientific and other sector (industry, government, etc.) tools and perspectives. However, developing effective research teams that cross such boundaries is difficult. This book demonstrates the importance of transdisciplinarity, describes challenges to such teamwork, and provides solutions for overcoming these challenges. It includes case studies of transdisciplinary teamwork, showing how these solutions have helped groups to develop better understandings of environmental problems and potential responses.
Brill’s Companion to Classics in the Early Americas
Brill’s Companion to Classics in the Early Americas opens a window onto classical receptions across the Hispanophone, Lusophone, Francophone and Anglophone Americas during the early modern period, examining classical reception as a phenomenon in transhemispheric perspective for the first
Ethnobotany of the Mountain Regions of Brazil
Research in recent years has increasingly shifted away from purely academic research, and into applied aspects of the discipline, including climate change research, conservation, and sustainable development. It has by now widely been recognized that “traditional” knowledge is always in flux and adapting to a quickly changing environment. Trends of globalization, especially the globalization of plant markets, have greatly influenced how plant resources are managed nowadays. While ethnobotanical studies are now available from many regions of the world, no comprehensive encyclopedic series focusing on the worlds mountain regions is available in the market. Scholars in plant sciences worldwi...
Smart Systems
This book aims to highlight the strength and state-of-art of some techniques and methods applied to intelligent systems. Rather to cover the variety of techniques and methods available in the literature, which is out of scope of this book, it focuses on those consolidated and applied and on those with high potential of implementation to smart systems. This book has fourteen chapters covering abroad range of topics in communications. The first three chapters are devoted to state-of-art and review papers on planar filters, unmanned aerial vehicles (UAV), negative group delay, nanoclusters, and tunable lights, while the remain chapters cover specific topics such as smart monitoring, V2I, high-speed links, RF and Optical sensors, composite material, metamaterial, energy harvesting, radar, SWIPT, and electromagnetic sources.
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