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Bone and Joint Infections
Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.
Polymyxin Antibiotics
It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; howev...
Applied Pharmacokinetics & Pharmacodynamics
The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.
Socio-Legal Struggles for Indigenous Self-Determination in Latin America
This book is an interdisciplinary study of struggles for indigenous self-determination and the recognition of indigenous’ territorial rights in Latin America. Studies of indigenous peoples’ opposition to extractive industries have tended to focus on its economic, political or social aspects, as if these were discrete dimensions of the conflict. In contrast, this book offers a comprehensive and interdisciplinary understanding of the tensions between indigenous peoples’ territorial rights and the governance of extractive industries and related state developmental policies. Analysing the contentious process pushed by indigenous peoples for implementing pluri-nationality against extractive...
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical rese...
Antibiotic Pharmacodynamics
This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Nationalism Reframed
This study of nationalism in Eastern Europe and the former Soviet Union develops an original account of the interlocking and opposed nationalisms of national minorities, the nationalizing states in which they live, and the external national homelands to which they are linked by external ties.
Antimicrobial Drug Resistance
The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant o...
Compromise and the American Founding
An original interpretation of 'the people's two bodies' that illuminates the opposite attitudes toward compromise throughout the American founding.
When More Is Not Better
American democratic capitalism is in danger. How can we save it? For its first two hundred years, the American economy exhibited truly impressive performance. The combination of democratically elected governments and a capitalist system worked, with ever-increasing levels of efficiency spurred by division of labor, international trade, and scientific management of companies. By the nation's bicentennial celebration in 1976, the American economy was the envy of the world. But since then, outcomes have changed dramatically. Growth in the economic prosperity of the average American family has slowed to a crawl, while the wealth of the richest Americans has skyrocketed. This imbalance threatens ...
