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Molecular Biology of the Hepatitis B Virus
Molecular Biology of the Hepatitis B Virus presents a comprehensive account of the various molecular aspects of the life cycle of the hepatitis B virus (HBV). Topics covered include the animal model systems, sequence data on the hepadnavirus genomes, the transcripts coded for the biral genome and sequence elements involved in regulating their expression, hepadnavirus replication, and analysis of the various HBV gene products and their role in virion synthesis and assembly. Other important features of the book include its discussions of the consequences of long term exposure to hepadnavirus infection and its association with hepatocellular carcinoma, the use of recombinant technologies in the generation of second generation vaccines, and the utilization of recombinant technologies to analyze an immune mediated disease. Researchers studying hepadnaviruses will find a wealth of information in this essential reference volume.
Neuroscience in the 21st Century
Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people glob...
Molecules of Life & Mutations
This book provides insights into the structures and functions of 130 of the most important biomolecules and their interactions with other endogenous or exogenous molecules. These interactions are illustrated by 3-dimensional images of their atomic structures rather than by abstract formulas or acronyms. The author has compiled an extraordinary collection of molecules which he has visualized in pictures of stunning clarity and beauty by applying molecular modelling software to their atomic coordinate files (deposited in the Brookhaven Protein Data Bank (PDB)). Together with short explanatory texts they provide the reader with a deepened understanding of biological phenomena in the normal as well as the diseased organism.
The Hippocampus Book
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
NMDA Receptors
This fully updated volume explores N-Methyl-D-aspartate receptors (NMDARs), and the structure-function relations, principles, and rules that govern how NMDARs operate in brain processing under normal and pathological conditions. With chapters from leading laboratories around the world, this book examines the expression and purification of diverse NMDA receptor subtypes, gene targeting and generation of conditional NMDAR mutant mouse lines, studies of NMDARs in zebrafish, electrophysiological studies, NMDARs modeling in silico, drug development with artificial intelligence, and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, NMDA Receptors: Methods and Protocols, Second Edition serves as an ideal guide to the diversity of possible approaches in the field of NMDARs and the progress that has been made in recent years.
Follicle Stimulating Hormone
The chapters in this book represent presentations at the first meeting ever held on the regulation and actions of follicle stimulating hormone. The meeting took place on the campus of Northwestern University, Evanston, Illinois, from October 25 to 28, 1990. The idea for this meeting was conceived by Neena B. Schwartz, and the valuable advice of the organizing committee contributed greatly to its scientific success. We gratefully acknowledge the funding and coordination of this meeting by Serono Symposia, USA. We also wish to acknowledge the financial contributions made by Northwestern University. We especially thank the invited speakers, poster presenters, and discussion participants who pro...
Sourcebook of Models for Biomedical Research
The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarit...
