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Metabolic Control
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional mechanisms in metabolic pathway control over metabolic communication routes in physiology and pathophysiology to current treatment modalities and options in metabolic disorders, including type 2 diabetes and obesity. Dedicated chapters by leading experts in their fields provide a concise overview over important areas in metabolic research at a molecular level, including the role of the central nervous system in metabolism, inflammation and metabolism, pancreatic hormone signaling, brown adipose tissue, and therapeutic concepts.
Plasticity and Metabolic Switching in Adipose Tissue Macrophages
Macrophages are the most common immune cells present in adipose tissues. These adipose tissue macrophages (ATMs) have an important role in regulating homeostasis and contributing to the metabolically harmful chronic inflammation seen in some obese individuals. Macrophages are cells exhibiting plasticity, that is to alter their polarization between pro- and anti-inflammatory phenotypes, in response to stimuli in their microenvironments. There has been a deal of evidence supporting the heterogeneity of these ATM populations, however, research into their differential functionality, developmental origin, and phenotype warrants further research to reach a consensus. Further questions remain regar...
Metabolic Control
The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional mechanisms in metabolic pathway control over metabolic communication routes in physiology and pathophysiology to current treatment modalities and options in metabolic disorders, including type 2 diabetes and obesity. Dedicated chapters by leading experts in their fields provide a concise overview over important areas in metabolic research at a molecular level, including the role of the central nervous system in metabolism, inflammation and metabolism, pancreatic hormone signaling, brown adipose tissue, and therapeutic concepts.
Campus de la Diagonal
Aquest llibre presenta una reflexió acadèmica i professional al Campus de la Diagonal amb un ampli ventall d’idees urbanístiques que permeten establir un nou escenari universitari i millorar la relació amb la ciutat..Durant els anys seixanta i setanta del segle passat es varen realitzar diversos projectes d’edificis i recintes universitaris de gran interès (de Carlo, Candilis, Sert). També es varen publicar notables estudis sobre la relació entre la ciutat i la universitat..Feia, però, força anys que aquestes qüestions no semblaven ocupar l’agenda d’arquitectes, urbanistes i responsables universitaris. Per això sembla tan oportú l’esforç de recollir en aquestes poc més de dues-centes planes tot un seguit de riques reflexions i de projectes, tant aquells que responen a encàrrecs concrets de la UB i de la UPC, com aquells que han realitzat un conjunt d’estudiants per recosir i fer ciutat d’una munió d’edificis, sovint de caràcter abstret i poc permeable, tallats per una avinguda de grans dimensions i disposats sense cap visió de conjunt.
