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Molecular Biology of B-Cell and T-Cell Development
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cell...
Ahead of the Curve
A biography of one of America's most famous and important molecular biologists.
The Black Box of Biology
In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology w...
Natural Obsessions
Describes the search for the genes that control cancer.
Scientific Fraud
None
Medical genetics 1
Medical genetics encompasses many different areas, including the clinical practice of doctors, genetic counselors and nutritionists, clinical diagnostic laboratory activities and research on the causes and inheritance of genetic disorders. Examples of conditions that are within the scope of medical genetics include birth defects and dysmorphology, mental retardation, autism, mitochondrial disorders, skeletal dysplasia, connective tissue disorders, cancer genetics, teratogens and prenatal diagnosis. Medical genetics is becoming increasingly relevant for many common diseases. Overlaps with other medical specialties are beginning to emerge, as recent advances in genetics are revealing etiologie...
Organization of human chromosomes
Since 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data is used worldwide in biomedical sciences, anthropology, forensic medicine and other branches of science. Recent results suggest that most of the vast amounts of non-coding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture and signals that control epigenetic inheritance. Summary of the contents of this book: Organization of human chromosomes Nuclear organization and rearrangements in pluripotent cells Organization of the human genome Repetitive elements and human disorders Mitochondrial DNA Cell division The cell cycle The phases of mitosis The human karyotype Karyotype analysis Types of staining Meiosis Cytokinesis The Second Meiotic Division (Meiosis II)
The Baltimore Case: A Trial of Politics, Science, and Character
"You read with a rising sense of despair and outrage, and you finish it as if awakening from a nightmare only Kafka could have conceived."--Christopher Lehmann-Haupt, New York Times David Baltimore won the Nobel Prize in medicine in 1975. Known as a wunderkind in the field of immunology, he rose quickly through the ranks of the scientific community to become the president of the distinguished Rockefeller University. Less than a year and a half later, Baltimore resigned from his presidency, citing the personal toll of fighting a long battle over an allegedly fraudulent paper he had collaborated on in 1986 while at MIT. From the beginning, the Baltimore case provided a moveable feast for those eager to hold science more accountable to the public that subsidizes its research. Did Baltimore stonewall a legitimate government inquiry? Or was he the victim of witch hunters? The Baltimore Case tells the complete story of this complex affair, reminding us how important the issues of government oversight and scientific integrity have become in a culture in which increasingly complicated technology widens the divide between scientists and society.
