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Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II)
The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage b...
Kidney Protection
Kidney disease affects approximately ten percent of the population worldwide, with more than 2.6 million individuals estimated to be receiving renal replacement therapy. Chronic kidney disease (CKD) is fast becoming a major public health issue, with increasing incidence and death rates throughout the world. Many strategies have been proposed to reduce the growing burden of kidney disease; but while early identification and improved access to renal replacement therapies and transplantation are important, they are unlikely to solve this enormous problem. Efforts focused on primary prevention, protection, and slowing the progression of kidney disease are needed as well. Renal protection is a vi...
Clinical Perspectives and Targeted Therapies in Apoptosis
Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent cl...
Clinical Perspectives and Targeted Therapies in Apoptosis
Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.
Nanoparticulates as Drug Carriers
Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry...
Dead Silence
V. CONCLUSION AND RECOMMENDATIONS
Fighting for Faith and Nation
The ethnic and religious violence that characterized the late twentieth century calls for new ways of thinking and writing about politics. Listening to the voices of people who experience political violence—either as victims or as perpetrators—gives new insights into both the sources of violent conflict and the potential for its resolution. Drawing on her extensive interviews and conversations with Sikh militants, Cynthia Keppley Mahmood presents their accounts of the human rights abuses inflicted on them by the state of India as well as their explanations of the philosophical tradition of martyrdom and meaningful death in the Sikh faith. While demonstrating how divergent the world views of participants in a conflict can be, Fighting for Faith and Nation gives reason to hope that our essential common humanity may provide grounds for a pragmatic resolution of conflicts such as the one in Punjab which has claimed tens of thousands of lives in the past fifteen years.
An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy
This update on SARS-CoV-2 focuses on basic knowledge about the virus and COVID-19 treatment. Chapters present basic information about the disease and its treatment. The virology, epidemiology, etiology, and damage response framework of SARS-CoV-2 are also discussed in detail. The book also covers recent topics of interest to pharmacology scholars such as the immunopathogenesis of SARS-CoV2, nanotechnology, repurposed drug treatments, COVID-19 vaccines, and phytomedicine for COVID-19 therapeutics. Readers in pharmacology, virology and medicine will find the book a simple, yet informative update on SARS-CoV-2 and COVID-19 treatment.
The Sikhs
Five hundred years ago, Guru Nanak founded the Sikh faith in India. The Sikhs defied the caste system; rejected the authority of Hindu priests; forbade magic and idolatry; and promoted the equality of men and women -- beliefs that incurred the wrath of both Hindus and Muslims. In the centuries that followed, three of Nanak's nine successors met violent ends, and his people continued to battle hostile regimes. The conflict has raged into our own time: in 1984 the Golden Temple of Amritsar -- the holy shrine of the Sikhs--was destroyed by the Indian Army. In retaliation, Sikh bodyguards assassinated Prime Minister Indira Gandhi. Now, Patwant Singh gives us the compelling story of the Sikhs -- ...
Poly(ADP-Ribosyl)ation
This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
