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Regulation of G1 Phase Progression
In this contribution, several specialists describe the current knowledge on the molecular networks that regulate cell cycle progression, with an emphasis on the G1 phase of the cell cycle. The first part of Regulation of G1 Phase Progression is concerned with the individual molecules that form the network, including cyclins, cyclin-dependent kinases, inhibitors of these kinases and retinoblastoma and p53. The second section describes the signaling cascades by which external factors influence the cell cycle network, including mitogens, the extracellular matrix, nutrients and oxygen radicals. The last section describes the effects of specific external conditions on cell cycle progression and are presented such as serum starvation and subsequent re-addition and stress conditions (heat, osmolarity). The final two chapters describe the relation between cell cycle progression with cell differentiation and with apoptosis.
Projective Geometry and Formal Geometry
The aim of this monograph is to introduce the reader to modern methods of projective geometry involving certain techniques of formal geometry. Some of these methods are illustrated in the first part through the proofs of a number of results of a rather classical flavor, involving in a crucial way the first infinitesimal neighbourhood of a given subvariety in an ambient variety. Motivated by the first part, in the second formal functions on the formal completion X/Y of X along a closed subvariety Y are studied, particularly the extension problem of formal functions to rational functions. The formal scheme X/Y, introduced to algebraic geometry by Zariski and Grothendieck in the 1950s, is an an...
Arrangements of Hyperplanes
An arrangement of hyperplanes is a finite collection of codimension one affine subspaces in a finite dimensional vector space. Arrangements have emerged independently as important objects in various fields of mathematics such as combinatorics, braids, configuration spaces, representation theory, reflection groups, singularity theory, and in computer science and physics. This book is the first comprehensive study of the subject. It treats arrangements with methods from combinatorics, algebra, algebraic geometry, topology, and group actions. It emphasizes general techniques which illuminate the connections among the different aspects of the subject. Its main purpose is to lay the foundations o...
Proteins, Enzymes, Genes
In this book a distinguished scientist-historian offers a critical account of how biochemistry and molecular biology emerged as major scientific disciplines from the interplay of chemical and biological ideas and practice. Joseph S. Fruton traces the historical development of these disciplines from antiquity to the present time, examines their institutional settings, and discusses their impact on medical, pharmaceutical, and agricultural practice.
Asymptotic Differential Algebra and Model Theory of Transseries
Asymptotic differential algebra seeks to understand the solutions of differential equations and their asymptotics from an algebraic point of view. The differential field of transseries plays a central role in the subject. Besides powers of the variable, these series may contain exponential and logarithmic terms. Over the last thirty years, transseries emerged variously as super-exact asymptotic expansions of return maps of analytic vector fields, in connection with Tarski's problem on the field of reals with exponentiation, and in mathematical physics. Their formal nature also makes them suitable for machine computations in computer algebra systems. This self-contained book validates the int...
Field Extensions and Galois Theory
This 1984 book aims to make the general theory of field extensions accessible to any reader with a modest background in groups, rings and vector spaces. Galois theory is regarded amongst the central and most beautiful parts of algebra and its creation marked the culmination of generations of investigation.
Topics in Field Theory
This monograph gives a systematic account of certain important topics pertaining to field theory, including the central ideas, basic results and fundamental methods.Avoiding excessive technical detail, the book is intended for the student who has completed the equivalent of a standard first-year graduate algebra course. Thus it is assumed that the reader is familiar with basic ring-theoretic and group-theoretic concepts. A chapter on algebraic preliminaries is included, as well as a fairly large bibliography of works which are either directly relevant to the text or offer supplementary material of interest.
Difference Algebra
Difference algebra grew out of the study of algebraic difference equations with coefficients from functional fields. The first stage of this development of the theory is associated with its founder, J.F. Ritt (1893-1951), and R. Cohn, whose book Difference Algebra (1965) remained the only fundamental monograph on the subject for many years. Nowadays, difference algebra has overgrown the frame of the theory of ordinary algebraic difference equations and appears as a rich theory with applications to the study of equations in finite differences, functional equations, differential equations with delay, algebraic structures with operators, group and semigroup rings. The monograph is intended for graduate students and researchers in difference and differential algebra, commutative algebra, ring theory, and algebraic geometry. The book is self-contained; it requires no prerequisites other than the knowledge of basic algebraic concepts and a mathematical maturity of an advanced undergraduate.
Classification of Algebraic Varieties
Fascinating and surprising developments are taking place in the classification of algebraic varieties. The work of Hacon and McKernan and many others is causing a wave of breakthroughs in the minimal model program: we now know that for a smooth projective variety the canonical ring is finitely generated. These new results and methods are reshaping the field. Inspired by this exciting progress, the editors organized a meeting at Schiermonnikoog and invited leading experts to write papers about the recent developments. The result is the present volume, a lively testimony to the sudden advances that originate from these new ideas. This volume will be of interest to a wide range of pure mathematicians, but will appeal especially to algebraic and analytic geometers.
