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Periostin
This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.
Cancer Disparities
There has been remarkable progress in understanding, preventing, detecting, diagnosing, and treating cancer, resulting in a reduction of cancer incidence and mortality in the United States. Despite this, the cancer burden varies considerably by race/ethnicity and socioeconomic status. Cancer incidence rates vary markedly between racial/ethnic groups, but even more startling are the differences in outcome across groups. Cancer Disparities: Causes and Evidence-Based Solutions helps readers understand the scope and causes of this inequity by providing a detailed analysis of the many factors that result in cancer disparities across the cancer continuum, including the role of race/ethnicity, soci...
Intelligent Tutoring Systems
The 10th International Conference on Intelligent Tutoring Systems, ITS 2010, cont- ued the bi-annual series of top-flight international conferences on the use of advanced educational technologies that are adaptive to users or groups of users. These highly interdisciplinary conferences bring together researchers in the learning sciences, computer science, cognitive or educational psychology, cognitive science, artificial intelligence, machine learning, and linguistics. The theme of the ITS 2010 conference was Bridges to Learning, a theme that connects the scientific content of the conf- ence and the geography of Pittsburgh, the host city. The conference addressed the use of advanced technolog...
Rehabilitation Science in Context
The focus of this book lies on novel aspects of rehabilitation medicine used as a treatment tool in both physical and mental spheres. The articles cover a diverse spectrum, such as rehabilitation in orthopedic pathologies, the exemplary of which is knee joint degeneration, in perioperative metastatic cancer diseases, or in neural degeneration requiring a transplant of donor nerve fibers into the defunct nerve. Advanced research studies involving proprioceptive neuromuscular facilitation, photobiomodulation, or yoga meditative techniques to regain functional ability are dealt with. The topic is expanded by a comprehensive picture of chosen molecular, genetically underpinned, diagnostics in hepatitis C infections and of novel ideas in drug design holding a curative promise in central neurodegeneration, such as development of brain-blood-barrier permeable oleic derivatives of the hydrophilic dopamine compound. The emerging rehabilitative modes and applications are posed to influence future health care delivery. The state-of-the art research is addressed to scientists, clinicians, therapists, and allied health care professionals.
Osteoporosis, Two-Volume Set
Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.Key Features* The source on osteoporosis* Written by expert investigators in their respective fields* Each chapter provides timely, comprehensive, and scholarly discussion* Fully illustrated in color and black & white* Covers everything from basic anatomy and physiology to diagnosis, management and treatment
Progress in Heterocyclic Chemistry
Progress in Heterocyclic Chemistry: Volume 34, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), contains both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. Highlight chapters in Volume 34 are all written by leading researchers in their field, thus constituting a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2021. As with previous volumes in the series, Volume 34 will enable academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way. - Recognized as the premiere review of heterocyclic chemistry - Includes contributions from leading researchers in the field - Provides a systematic survey of the important 2021 heterocyclic chemistry literature - Presents articles on new and developing topics of interest to heterocyclic chemist
Clinical Medicine Research
This book presents an update on new trends and developments in broadly defined medical disciplines. The whole range of multidisciplinary topics are tackled, regarded as being important for advancing the understanding of disease pathogenicity, diagnostic methods, and patient management. The topics include a holistic approach to physiotherapy, with proprioceptive neuromuscular facilitation at the core of it, potential ways to protect kidneys during ischemic coronary interventions, and psychosocial aspects in cancer survivors. Other topics deal with growth hormone deficiency in short children and responses of molecular markers of bone metabolism to growth hormone replacement therapy and with th...
Disease Prevention and Health Promotion in Developing Countries
This book brings together two important discussions in public health in developing countries: an understanding of the burden of disease, health equity and social determinants of health; and biomathematical models, epidemiological studies and estimation of the direct and indirect cost of disease. The empirical chapters in the first part discuss aspects of disease prevention and health promotion in developing countries, with a particular focus on countries that are part of the World Health Organization’s Eastern Mediterranean Region and the African Region. Health equity and social determinants of health constitute a cornerstone of this book, with the widespread recognition that addressing the social determinants of health is crucial not only for improving general health but importantly for reducing unfair and remediable health inequalities. Using mathematical models, epidemiological studies and statistical estimation of costs, the second part of this book shows the opportunities that exist for developing countries to prevent disease and promote health by adopting cost-effective strategies and cost–benefit analyses.
Muscle 2-Volume Set
Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.
Disaster Management and Emergency Medicine in the Asia-Pacific Region: Current Practices and Future Directions
Around the world, people and societies are at risk of being affected by disasters, both natural and man-made. In the face of climate change and human activity, the threat posed by unexpected disasters is likely to increase in future. This book, the first of its kind in Hong Kong, offers insights from experts in healthcare and higher education both locally and further afield. Some of the authors have first-hand experience with various elements of disaster management through such events as the 2008 earthquake in Sichuan, the COVID-19 pandemic, and large-scale competitions including the Standard Chartered Hong Kong Marathon. Key learnings and recommendations are presented in three sections: dis...
