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The Curve of Time
A beloved and bestselling Pacific Northwest classic, now available in paperback from Harbour Publishing! Widowed at the age of thirty-five, Muriel Wylie Blanchet packed up her five children in the summers that followed and set sail aboard the twenty-five-foot Caprice. For fifteen summers, in the 1920s and 1930s, the family explored the coves and islands of the BC coast, encountering settlers and hermits, hungry bears and dangerous tides, and falling under the spell of the region’s natural beauty. Driven by curiosity, the family followed the quiet coastline, and Blanchet—known as Capi, after her boat—recorded their wonder as they threaded their way between the snowfields, slept under the bright stars and wandered through Indigenous winter villages left empty in the summer months. The Curve of Time weaves the story of these years into a memoir that has inspired generations to seek out their own adventures on the wild west coast. First published in 1961, less than a year before the author died, Blanchet’s captivating work has become a classic of travel writing, and one of the bestselling BC books of all time.
Wylie
'When people gave up on Wylie, Wylie refused to give up on people.' For a street dog born in the city of Kandahar, Afghanistan, to be crowned top dog at Scruffts, a competition for crossbreeds held during Crufts, the largest dog show on earth, is nothing short of a miracle. But for Wylie, the gentle, cropped eared ball of fur, miracles seemed to happen quite regularly. Beaten and abused while being used as a bait dog, Wylie suffered terrible injuries that needed urgent treatment. Rescued close to death, with hacked off ears and a severed tail, he was attended to by soldiers who feared he would not last the night. Astonishingly he did, only to return days later with new injuries. However a lifeline came when he was handed over to animal welfare Charity Nowzad and flown to Britain in the hope of finding a new life. But would anyone take a chance on a seemingly nervous and undomesticated stray? Luckily for Wylie his biggest adventure yet was about to begin... This is the incredible and heart-warming story, full of tragedy and triumph, of a dog who never gave up hope.
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Molecular Basis and Gene Therapies of Cystic Fibrosis
Summary of Genes. Thirty years ago, the gene responsible for cystic fibrosis (CF), a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, was identified. This progress has considerably changed our understanding of the pathophysiology of CF and has paved the way for the development of novel and specific therapies for the disease. The CFTR gene contains 27 exons and is characterized by a frequent three base pair deletion of the p.Phe508del. As a result of collaborative work, today more than 2000 mutations have been reported in the gene, and their impact on protein function is now more evident and useful in designing new strategies to co...
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Leukocyte Trafficking
Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.
Fatigue in Multiple Sclerosis
Dear Readers, If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.
Podocytopathy
The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
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