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Immigrant and Ethnic-Minority Writers since 1945
This study analyses how immigrant and ethnic-minority writers have challenged the understanding of certain national literatures and have markedly changed them. In other national contexts, ideologies and institutions have contained the challenge these writers pose to national literatures. Case studies of the emergence and recognition of immigrant and ethnic-minority writing come from fourteen national contexts. These include classical immigration countries, such as Canada and the United States, countries where immigration accelerated and entered public debate after World War II, such as the United Kingdom, France and Germany, as well as countries rarely discussed in this context, such as Brazil and Japan. Finally, this study uses these individual analyses to discuss this writing as an international phenomenon. Sandra R.G. Almeida, Maria Zilda F. Cury, Sarah De Mul, Sneja Gunew, Dave Gunning, Kristina Iwata-Weickgenannt, Martina Kamm, Liesbeth Minnaard, Maria Oikonomou, Wenche Ommundsen, Marie Orton, Laura Reeck, Daniel Rothenbühler, Cathy J. Schlund-Vials, Wiebke Sievers, Bettina Spoerri, Christl Verduyn, Sandra Vlasta.
Drug Discovery for Schizophrenia
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.
Plasticity in the Adult Brain: From Genes to Neurotherapy
In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.
Dementia in Clinical Practice
This publication summarizes the most recent advances in neurobiology, diagnostic approaches and therapeutics of the major dementing illnesses such as Alzheimer's disease, frontotemporal dementia, Lewy body disease, and vascular dementia. In a succinct, practical and comprehensive manner, it provides an updated view of the disorders likely to be encountered in a daily practice. Each section is focused on a major form of dementia and is organized following the same scheme reviewing the pathophysiology of the disease, its diagnostic challenges, its characteristic neuroimaging features, therapeutic interventions and patient management issues. Avoiding an overspecialized approach, the book bridges the gap between clinical practice, advanced imaging, recent therapeutics and basic sciences. Thus, it serves as an excellent guide for mental health professionals working in the field of dementia as well as primary care physicians and students.
Pan Vascular Medicine
The textbook provides an interdisciplinary and integrated perspective of modern vascular cure. Written by experts the text proceeds from fundamental principles to advanced concepts. The book is divided into four parts, each focusing on different basic concepts of vascular cure. All fundamental principles of the area are clearly explained to facilitate vascular diagnostics and treatment in clinical practice. It is aimed at junior practitioners and experts.
The Microbiological Quality of Food
The Microbiological Quality of Food: Foodborne Spoilers covers the microbiological spoilage of foods, with a focus on the spoilers, the foods themselves, and the signs of spoilage. The book addresses traditional spoilers (filamentous fungi, spore-forming bacteria, yeasts, SSO in fish), as well as some emerging spoilers (Pseudomonas), now recognized as primary targets. Sections also provide a brief overview of important foods (vegetables, milk and dairy products, meat, and fish) and addresses safety and economic loss. Details on the signs of spoilage, how to prevent spoilers, and methods of detecting spoilage and spoilage microorganisms in foods are also presented. This is an authoritative re...
Biobetters
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor produc...
Computational Approaches in Drug Discovery, Development and Systems Pharmacology
Computational Approaches in Drug Discovery, Development and Systems Pharmacology provides detailed information on the use of computers in advancing pharmacology. Drug discovery and development is an expensive and time-consuming practice, and computer-assisted drug design (CADD) approaches are increasing in popularity in the pharmaceutical industry to accelerate the process. With the help of CADD, scientists can focus on the most capable compounds so that they can minimize the synthetic and biological testing pains. This book examines success stories of CADD in drug discovery, drug development and role of CADD in system pharmacology, additionally including a focus on the role of artificial in...
Molecular Imaging
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