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Systems and Management Science by Extremal Methods
This volume, Systems and Management Science by Extremal Methods, is the second in a series dedicated to honoring and extending the work of Abraham Charnes. The first volume, entitled Extremal Methods and Systems Analysis (Springer Verlag, Berlin, 1980), was edited by A.V. Fiacco and K.O. Kortanek. Subtitled "An International Symposium on the Occasion of Abraham Charnes' Sixtieth Birthday," this first volume consisted of a selection from papers presented at a conference in honor of Professor Charnes held at The University of Texas at Austin in September 1977. This second volume consists of papers, to be described more fully below, that were presented in a similar 2 conference held at the IC Institute of The University of Texas at Austin, Texas, in October of 1987, to honor Dr. Charnes on his seventieth birthday. All these papers were written by scholars and scientists whose own work has been affected by the contributions of this distinguished scholar and educator over a long period of time.
Multilevel Optimization: Algorithms and Applications
Researchers working with nonlinear programming often claim "the word is non linear" indicating that real applications require nonlinear modeling. The same is true for other areas such as multi-objective programming (there are always several goals in a real application), stochastic programming (all data is uncer tain and therefore stochastic models should be used), and so forth. In this spirit we claim: The word is multilevel. In many decision processes there is a hierarchy of decision makers, and decisions are made at different levels in this hierarchy. One way to handle such hierar chies is to focus on one level and include other levels' behaviors as assumptions. Multilevel programming is the research area that focuses on the whole hierar chy structure. In terms of modeling, the constraint domain associated with a multilevel programming problem is implicitly determined by a series of opti mization problems which must be solved in a predetermined sequence. If only two levels are considered, we have one leader (associated with the upper level) and one follower (associated with the lower level).
Molecular Oncology, An Issue of Surgical Pathology Clinics - E-Book
Clinically accessible information for pathologists on the fast moving field of molecular pathology and oncology, addressing molecular and genetic approaches to the diagnosis and classification of tumors, predictive biomarkers for treatment response and disease progression. Recurrent in this series, summaries are provided of Key Features of tumor, Key molecular prognostic markers and therapeutic markers, Tumor suppressor genes, and Oncogenes. Topics include molecular pathology of: Breast, Gastrointestinal, Head and Neck, Genitourinary, Gynecologic, Hematopathology, Lung, Neuropathology, Pancreas/Biliary, and Sarcome.
Semi-Infinite Programming
Semi-infinite programming (SIP) deals with optimization problems in which either the number of decision variables or the number of constraints is finite. This book presents the state of the art in SIP in a suggestive way, bringing the powerful SIP tools close to the potential users in different scientific and technological fields. The volume is divided into four parts. Part I reviews the first decade of SIP (1962-1972). Part II analyses convex and generalised SIP, conic linear programming, and disjunctive programming. New numerical methods for linear, convex, and continuously differentiable SIP problems are proposed in Part III. Finally, Part IV provides an overview of the applications of SIP to probability, statistics, experimental design, robotics, optimization under uncertainty, production games, and separation problems. Audience: This book is an indispensable reference and source for advanced students and researchers in applied mathematics and engineering.
Generalized Inverses
This second edition accounts for many major developments in generalized inverses while maintaining the informal and leisurely style of the 1974 first edition. Added material includes a chapter on applications, new exercises, and an appendix on the work of E.H. Moore.
Molecular Diagnostics
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
Transportome Malfunction in the Cancer Spectrum
This is the first of three volumes in the "Ion Channels & Transporters in Tumor Biology" collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis. The authors highlight the role of the so-called transportome, which is defined by the entirety of ion transporters and ion channels. Thereby, readers will get a better understanding of the impact dysregulated ion transport has on the whole spectrum of cancer types. Cancers display deficiencies in several, sometimes interdependent members of the transportome. Clinicians will be interested in the fact that controlled expression of ion transport proteins dramatically impacts the life span of cancer patients, as shown in recent studies. These observations offer a promising outlook for biomedical scientists, as members of the transportome could be the tumor markers of tomorrow - both for diagnostic and therapeutic purposes. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.
