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Elizabeth Blackburn and the Story of Telomeres
The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking. Molecular biologist Elizabeth Blackburn—one of Time magazine's 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the mo...
The Mathematical Sciences' Role in Homeland Security
Mathematical sciences play a key role in many important areas of Homeland Security including data mining and image analysis and voice recognition for intelligence analysis, encryption and decryption for intelligence gathering and computer security, detection and epidemiology of bioterriost attacks to determine their scope, and data fusion to analyze information coming from simultaneously from several sources. This report presents the results of a workshop focusing on mathematical methods and techniques for addressing these areas. The goal of the workshop is to help mathematical scientists and policy makers understand the connections between mathematical sciences research and these homeland security applications.
AIDS and Accusation
Does the scientific 'theory' that HIV came to North America from Haiti stem from underlying attitudes of racism and ethnocentrism in the United States rather than from hard evidence? Paul Farmer answers with this ethnographic study of AIDS in a poor society.
Moving Mountains
In this work, Anne-Christine D'Adesky, an award-winning reporter, offers a global analysis of AIDS treatment and prevention, in countries from South Africa to China.
Mathematical Models in Population Biology and Epidemiology
The goal of this book is to search for a balance between simple and analyzable models and unsolvable models which are capable of addressing important questions on population biology. Part I focusses on single species simple models including those which have been used to predict the growth of human and animal population in the past. Single population models are, in some sense, the building blocks of more realistic models -- the subject of Part II. Their role is fundamental to the study of ecological and demographic processes including the role of population structure and spatial heterogeneity -- the subject of Part III. This book, which will include both examples and exercises, is of use to practitioners, graduate students, and scientists working in the field.
Scaling Up Treatment for the Global AIDS Pandemic
An estimated forty million people carry the human immunodeficiency virus (HIV), and five million more become newly infected annually. In recent years, many HIV-infected patients in wealthy nations have enjoyed significantly longer, good-quality lives as a result of antiretroviral therapy (ART). However, most infected individuals live in the poorest regions of the world, where ART is virtually nonexistent. The consequent death toll in these regionsâ€"especially sub-Saharan Africaâ€"is begetting economic and social collapse. To inform the multiple efforts underway to deploy antiretroviral drugs in resource-poor settings, the Institute of Medicine committee was asked to conduct an indepen...
'Captain of all these men of death'
Tuberculosis mortality in the United States and in Britain was declining in the late nineteenth century but rising in Ireland. Only in the first decade of the twentieth century did mortality from tuberculosis begin to fall and even then it remained higher in Ireland than in Britain and many other European nations throughout the first half of the twentieth century. Why Ireland’s pattern of tuberculosis mortality was different is the subject of this book. Several controversies in the history of tuberculosis epidemics are addressed; the degree to which poverty and standard of living played a part in the tuberculosis decline, the role of public health, urbanisation and gender. Because tuberculosis was comparatively higher in Ireland it remained a much more potent political issue well into the twentieth century and the interaction between Ireland’s politics and the question of tuberculosis is discussed.
The Genomic Revolution
The 2005 conference, "The Genomic Revolution: Implications for Treatment and Control of Infectious Disease," attracted scientists, engineers, and medical researchers to work on new interdisciplinary responses using genomics to treat and control infectious diseases. Eleven conference working groups gave the participants eight hours to develop new research approaches to problems in infectious disease using genomics. Among the challenges were designing a new device to detect viral and bacterial pathogens; how best to use $100 million to prevent a future pandemic flu outbreak; how to improve rapid response to an outbreak of disease and reduce the cost of diagnostic tests; and how to sequence an ...
UN Millennium Development Library: Investing in Strategies to Reverse the Global Incidence of TB
The Millennium Development Goals, adopted at the UN Millennium Summit in 2000, are the world's targets for dramatically reducing extreme poverty in its many dimensions by 2015 income poverty, hunger, disease, exclusion, lack of infrastructure and shelter while promoting gender equality, education, health and environmental sustainability. These bold goals can be met in all parts of the world if nations follow through on their commitments to work together to meet them. Achieving the Millennium Development Goals offers the prospect of a more secure, just, and prosperous world for all. The UN Millennium Project was commissioned by United Nations Secretary-General Kofi Annan to develop a practica...
